SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A6URW3

- AMPPA_METVS

UniProt

A6URW3 - AMPPA_METVS

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
AMP phosphorylase
Gene
Mevan_1338
Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO By similarity.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei170 – 1701AMP; via amide nitrogen By similarity
Binding sitei205 – 2051AMP; via amide nitrogen By similarity
Active sitei258 – 2581Proton donor By similarity
Binding sitei266 – 2661AMP By similarity
Binding sitei290 – 2901AMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi196 – 2016AMP By similarity

GO - Molecular functioni

  1. AMP binding Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: InterPro

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
  3. pyrimidine nucleobase metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMVAN406327:GI04-1382-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylase (EC:2.4.2.57)
Short name:
AMPpase
Alternative name(s):
Nucleoside monophosphate phosphorylase
Short name:
NMP phosphorylase
Gene namesi
Ordered Locus Names:Mevan_1338
OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001107: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505AMP phosphorylaseUniRule annotation
PRO_0000314725Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi406327.Mevan_1338.

Structurei

3D structure databases

ProteinModelPortaliA6URW3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiESVPGFH.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6URW3-1 [UniParc]FASTAAdd to Basket

« Hide

MLFLNAKFID LDLGANAVIV NEEDLKGTSY YPQDRVLIES HSGSVLGILY    50
STKTMVQKGE VGIPVRKMKG ISLKEGEEVN LRHAEKPESI QFIKKKMDGQ 100
VLSPNEIRTI IDEIVSKKLS NIELAAFVTS TYVNGMNMEE IVEMTKRMAE 150
TGDMISWEKS LVVDIHSIGG VPGNKYALLS IPILAAAGIT IPKTSSRAIT 200
SPAGTADVME VLTNVELDEE ELKRVVKATN GCLVWGGGVN LAPADDIIIN 250
VERPVSIDPQ PQLLASVMAK KVATGIKYAV IDIPVGKGVK IKNEAEGAKL 300
ARKFIELGEL LNIRVECVLT YGGQPLGRAI GPALEAKEAL EALTDPKSAP 350
KSLIEKAISL AGILLELGGS AQIGDGQKLA WEILESGRAL EKFNQIIVEQ 400
GGTPKKPEEI ELGKYVEEVR SPIDGYIVGI NNTSITNVVK EAGAPRDKKA 450
GLLLNAKIGN KVKRGDILYT IYSGSEERLN SAVNLARRVY PVNVEGMMIE 500
RISKF 505
Length:505
Mass (Da):54,620
Last modified:August 21, 2007 - v1
Checksum:i4D915C86528E1F02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR55235.1.
RefSeqiWP_012066150.1. NC_009634.1.
YP_001323847.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR55235; ABR55235; Mevan_1338.
GeneIDi5325128.
KEGGimvn:Mevan_1338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR55235.1 .
RefSeqi WP_012066150.1. NC_009634.1.
YP_001323847.1. NC_009634.1.

3D structure databases

ProteinModelPortali A6URW3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 406327.Mevan_1338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR55235 ; ABR55235 ; Mevan_1338 .
GeneIDi 5325128.
KEGGi mvn:Mevan_1338.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi ESVPGFH.

Enzyme and pathway databases

BioCyci MVAN406327:GI04-1382-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_02132. AMP_phosphorylase.
InterProi IPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB / ATCC 35089 / DSM 1224.

Entry informationi

Entry nameiAMPPA_METVS
AccessioniPrimary (citable) accession number: A6URW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi