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Protein

AMP phosphorylase

Gene

Mevan_1338

Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei170AMP; via amide nitrogenUniRule annotation1
Binding sitei205AMP; via amide nitrogenUniRule annotation1
Active sitei258Proton donorUniRule annotation1
Binding sitei266AMPUniRule annotation1
Binding sitei290AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi196 – 201AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMVAN406327:GI04-1363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Mevan_1338
OrganismiMethanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147251 – 505AMP phosphorylaseAdd BLAST505

Interactioni

Protein-protein interaction databases

STRINGi406327.Mevan_1338.

Structurei

3D structure databases

ProteinModelPortaliA6URW3.
SMRiA6URW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013. Archaea.
COG0213. LUCA.
HOGENOMiHOG000252767.
KOiK18931.
OMAiVHSIGGV.
OrthoDBiPOG093Z01M3.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase. 1 hit.
InterProiView protein in InterPro
IPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
IPR000053. Thymidine/pyrmidine_PPase.
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiView protein in Pfam
PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiView protein in SMART
SM00941. PYNP_C. 1 hit.
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiView protein in PROSITE
PS00647. THYMID_PHOSPHORYLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A6URW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLNAKFID LDLGANAVIV NEEDLKGTSY YPQDRVLIES HSGSVLGILY
60 70 80 90 100
STKTMVQKGE VGIPVRKMKG ISLKEGEEVN LRHAEKPESI QFIKKKMDGQ
110 120 130 140 150
VLSPNEIRTI IDEIVSKKLS NIELAAFVTS TYVNGMNMEE IVEMTKRMAE
160 170 180 190 200
TGDMISWEKS LVVDIHSIGG VPGNKYALLS IPILAAAGIT IPKTSSRAIT
210 220 230 240 250
SPAGTADVME VLTNVELDEE ELKRVVKATN GCLVWGGGVN LAPADDIIIN
260 270 280 290 300
VERPVSIDPQ PQLLASVMAK KVATGIKYAV IDIPVGKGVK IKNEAEGAKL
310 320 330 340 350
ARKFIELGEL LNIRVECVLT YGGQPLGRAI GPALEAKEAL EALTDPKSAP
360 370 380 390 400
KSLIEKAISL AGILLELGGS AQIGDGQKLA WEILESGRAL EKFNQIIVEQ
410 420 430 440 450
GGTPKKPEEI ELGKYVEEVR SPIDGYIVGI NNTSITNVVK EAGAPRDKKA
460 470 480 490 500
GLLLNAKIGN KVKRGDILYT IYSGSEERLN SAVNLARRVY PVNVEGMMIE

RISKF
Length:505
Mass (Da):54,620
Last modified:August 21, 2007 - v1
Checksum:i4D915C86528E1F02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA. Translation: ABR55235.1.
RefSeqiWP_012066150.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR55235; ABR55235; Mevan_1338.
GeneIDi5325128.
KEGGimvn:Mevan_1338.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAMPPA_METVS
AccessioniPrimary (citable) accession number: A6URW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: June 7, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families