A6URW3 (TYPH_METVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Mevan_1338

Organism

Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]

Taxonomic identifier

406327 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus vannielii

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314725

Sequences

	Sequence		Length	Mass (Da)
	A6URW3 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 4D915C86528E1F02	FASTA	505	54,620
	10 20 30 40 50 60 MLFLNAKFID LDLGANAVIV NEEDLKGTSY YPQDRVLIES HSGSVLGILY STKTMVQKGE 70 80 90 100 110 120 VGIPVRKMKG ISLKEGEEVN LRHAEKPESI QFIKKKMDGQ VLSPNEIRTI IDEIVSKKLS 130 140 150 160 170 180 NIELAAFVTS TYVNGMNMEE IVEMTKRMAE TGDMISWEKS LVVDIHSIGG VPGNKYALLS 190 200 210 220 230 240 IPILAAAGIT IPKTSSRAIT SPAGTADVME VLTNVELDEE ELKRVVKATN GCLVWGGGVN 250 260 270 280 290 300 LAPADDIIIN VERPVSIDPQ PQLLASVMAK KVATGIKYAV IDIPVGKGVK IKNEAEGAKL 310 320 330 340 350 360 ARKFIELGEL LNIRVECVLT YGGQPLGRAI GPALEAKEAL EALTDPKSAP KSLIEKAISL 370 380 390 400 410 420 AGILLELGGS AQIGDGQKLA WEILESGRAL EKFNQIIVEQ GGTPKKPEEI ELGKYVEEVR 430 440 450 460 470 480 SPIDGYIVGI NNTSITNVVK EAGAPRDKKA GLLLNAKIGN KVKRGDILYT IYSGSEERLN 490 500 SAVNLARRVY PVNVEGMMIE RISKF

References

[1]

"Complete sequence of Methanococcus vannielii SB." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000742 Genomic DNA. Translation: ABR55235.1.
RefSeq	YP_001323847.1. NC_009634.1.
3D structure databases
ProteinModelPortal	A6URW3.
ModBase	Search...
Protein-protein interaction databases
STRING	406327.Mevan_1338.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR55235; ABR55235; Mevan_1338.
GeneID	5325128.
KEGG	mvn:Mevan_1338.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	MVAN406327:GI04-1389-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_METVS

Accession

Primary (citable) accession number: A6URW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program