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A6URW3

- AMPPA_METVS

UniProt

A6URW3 - AMPPA_METVS

Protein

AMP phosphorylase

Gene

Mevan_1338

Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

    Catalytic activityi

    AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei170 – 1701AMP; via amide nitrogenUniRule annotation
    Binding sitei205 – 2051AMP; via amide nitrogenUniRule annotation
    Active sitei258 – 2581Proton donorUniRule annotation
    Binding sitei266 – 2661AMPUniRule annotation
    Binding sitei290 – 2901AMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi196 – 2016AMPUniRule annotation

    GO - Molecular functioni

    1. AMP binding Source: UniProtKB-HAMAP
    2. phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
    3. pyrimidine nucleobase metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMVAN406327:GI04-1382-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
    Short name:
    AMPpaseUniRule annotation
    Alternative name(s):
    Nucleoside monophosphate phosphorylaseUniRule annotation
    Short name:
    NMP phosphorylaseUniRule annotation
    Gene namesi
    Ordered Locus Names:Mevan_1338
    OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
    Taxonomic identifieri406327 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000001107: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505AMP phosphorylasePRO_0000314725Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi406327.Mevan_1338.

    Structurei

    3D structure databases

    ProteinModelPortaliA6URW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiESVPGFH.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_02132. AMP_phosphorylase.
    InterProiIPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6URW3-1 [UniParc]FASTAAdd to Basket

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    MLFLNAKFID LDLGANAVIV NEEDLKGTSY YPQDRVLIES HSGSVLGILY    50
    STKTMVQKGE VGIPVRKMKG ISLKEGEEVN LRHAEKPESI QFIKKKMDGQ 100
    VLSPNEIRTI IDEIVSKKLS NIELAAFVTS TYVNGMNMEE IVEMTKRMAE 150
    TGDMISWEKS LVVDIHSIGG VPGNKYALLS IPILAAAGIT IPKTSSRAIT 200
    SPAGTADVME VLTNVELDEE ELKRVVKATN GCLVWGGGVN LAPADDIIIN 250
    VERPVSIDPQ PQLLASVMAK KVATGIKYAV IDIPVGKGVK IKNEAEGAKL 300
    ARKFIELGEL LNIRVECVLT YGGQPLGRAI GPALEAKEAL EALTDPKSAP 350
    KSLIEKAISL AGILLELGGS AQIGDGQKLA WEILESGRAL EKFNQIIVEQ 400
    GGTPKKPEEI ELGKYVEEVR SPIDGYIVGI NNTSITNVVK EAGAPRDKKA 450
    GLLLNAKIGN KVKRGDILYT IYSGSEERLN SAVNLARRVY PVNVEGMMIE 500
    RISKF 505
    Length:505
    Mass (Da):54,620
    Last modified:August 21, 2007 - v1
    Checksum:i4D915C86528E1F02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000742 Genomic DNA. Translation: ABR55235.1.
    RefSeqiWP_012066150.1. NC_009634.1.
    YP_001323847.1. NC_009634.1.

    Genome annotation databases

    EnsemblBacteriaiABR55235; ABR55235; Mevan_1338.
    GeneIDi5325128.
    KEGGimvn:Mevan_1338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000742 Genomic DNA. Translation: ABR55235.1 .
    RefSeqi WP_012066150.1. NC_009634.1.
    YP_001323847.1. NC_009634.1.

    3D structure databases

    ProteinModelPortali A6URW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 406327.Mevan_1338.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR55235 ; ABR55235 ; Mevan_1338 .
    GeneIDi 5325128.
    KEGGi mvn:Mevan_1338.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi ESVPGFH.

    Enzyme and pathway databases

    BioCyci MVAN406327:GI04-1382-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_02132. AMP_phosphorylase.
    InterProi IPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB / ATCC 35089 / DSM 1224.

    Entry informationi

    Entry nameiAMPPA_METVS
    AccessioniPrimary (citable) accession number: A6URW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3