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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine/guanine phosphoribosyltransferase (hpt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

BioCyciMVAN406327:G1G99-1190-MONOMER
UniPathwayiUPA00591; UER00648

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:Mevan_1150
OrganismiMethanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003293771 – 185Hypoxanthine/guanine phosphoribosyltransferaseAdd BLAST185

Proteomic databases

PRIDEiA6URC7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi406327.Mevan_1150

Structurei

3D structure databases

ProteinModelPortaliA6URC7
SMRiA6URC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00030 Archaea
COG0503 LUCA
HOGENOMiHOG000228520
KOiK00759
OMAiFIHPISD
OrthoDBiPOG093Z0AYC

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01467 Hypx_phosphoribosyltr, 1 hit
InterProiView protein in InterPro
IPR026597 HGPRTase-like
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
PROSITEiView protein in PROSITE
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

A6URC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLLENSLE TCPIVKRGPY HYFIHPISDG VPLVEPELLR DVSTRVIKMI
60 70 80 90 100
DTNVDKIVTA EAMGIPIVTA VSIATDIPYV IMRKREYLLE GEVPVHQETG
110 120 130 140 150
YSKGELYLNG INKGDKVVIL DDVISTGGTL VAIIRALKRA GADIKDVVCI
160 170 180
IDRGQGKNIV EKETGYKVKT LVKIEVVDGK VKILE
Length:185
Mass (Da):20,452
Last modified:August 21, 2007 - v1
Checksum:i76493A1E75714A50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA Translation: ABR55049.1
RefSeqiWP_012065964.1, NC_009634.1

Genome annotation databases

EnsemblBacteriaiABR55049; ABR55049; Mevan_1150
GeneIDi5325737
KEGGimvn:Mevan_1150

Similar proteinsi

Entry informationi

Entry nameiHPRT_METVS
AccessioniPrimary (citable) accession number: A6URC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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