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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. hypoxanthine salvage Source: UniProtKB-HAMAP
  2. IMP salvage Source: UniProtKB-UniPathway
  3. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMVAN406327:GI04-1185-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:Mevan_1150
OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001107 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Hypoxanthine/guanine phosphoribosyltransferasePRO_0000329377Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi406327.Mevan_1150.

Structurei

3D structure databases

ProteinModelPortaliA6URC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000228520.
KOiK00759.
OMAiIATDIPY.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6URC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLLENSLE TCPIVKRGPY HYFIHPISDG VPLVEPELLR DVSTRVIKMI
60 70 80 90 100
DTNVDKIVTA EAMGIPIVTA VSIATDIPYV IMRKREYLLE GEVPVHQETG
110 120 130 140 150
YSKGELYLNG INKGDKVVIL DDVISTGGTL VAIIRALKRA GADIKDVVCI
160 170 180
IDRGQGKNIV EKETGYKVKT LVKIEVVDGK VKILE
Length:185
Mass (Da):20,452
Last modified:August 21, 2007 - v1
Checksum:i76493A1E75714A50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA. Translation: ABR55049.1.
RefSeqiWP_012065964.1. NC_009634.1.
YP_001323661.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR55049; ABR55049; Mevan_1150.
GeneIDi5325737.
KEGGimvn:Mevan_1150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA. Translation: ABR55049.1.
RefSeqiWP_012065964.1. NC_009634.1.
YP_001323661.1. NC_009634.1.

3D structure databases

ProteinModelPortaliA6URC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi406327.Mevan_1150.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR55049; ABR55049; Mevan_1150.
GeneIDi5325737.
KEGGimvn:Mevan_1150.

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000228520.
KOiK00759.
OMAiIATDIPY.

Enzyme and pathway databases

UniPathwayiUPA00591; UER00648.
BioCyciMVAN406327:GI04-1185-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB / ATCC 35089 / DSM 1224.

Entry informationi

Entry nameiHPRT_METVS
AccessioniPrimary (citable) accession number: A6URC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 21, 2007
Last modified: April 29, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.