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A6URA0

- COFC_METVS

UniProt

A6URA0 - COFC_METVS

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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. nucleotidyltransferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN406327:GI04-1157-MONOMER.
UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Mevan_1122
OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001107: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2242242-phospho-L-lactate guanylyltransferasePRO_0000398748Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi406327.Mevan_1122.

Structurei

3D structure databases

ProteinModelPortaliA6URA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1920.
HOGENOMiHOG000223639.
KOiK14941.
OMAiDLGEIFI.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

A6URA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAALIPVSP LSNVKSRLKE FLSSKERIDL IKNILLDTYE KVKSCVDACY
60 70 80 90 100
VVSKDDEILE FSKNLGIIPI KEDLNTKGLN EAIEYSLNII KEDSVLITPA
110 120 130 140 150
DVPLLKEENL ESIVKKSVEN SVIICPSRGG GTNLLLLNPK NCIKPQFEGF
160 170 180 190 200
SFLKHIKEAE INNLNIIKCH SFYTSIDINT VEDLGEIFIH GKDTKTYKFL
210 220
KNLNIEAFPK HSSAGRFNII RKSQ
Length:224
Mass (Da):25,209
Last modified:August 21, 2007 - v1
Checksum:i327C69B89D7C0FBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR55022.1.
RefSeqiWP_012065937.1. NC_009634.1.
YP_001323634.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR55022; ABR55022; Mevan_1122.
GeneIDi5326069.
KEGGimvn:Mevan_1122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR55022.1 .
RefSeqi WP_012065937.1. NC_009634.1.
YP_001323634.1. NC_009634.1.

3D structure databases

ProteinModelPortali A6URA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 406327.Mevan_1122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR55022 ; ABR55022 ; Mevan_1122 .
GeneIDi 5326069.
KEGGi mvn:Mevan_1122.

Phylogenomic databases

eggNOGi COG1920.
HOGENOMi HOG000223639.
KOi K14941.
OMAi DLGEIFI.

Enzyme and pathway databases

UniPathwayi UPA00071 .
BioCyci MVAN406327:GI04-1157-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
HAMAPi MF_02114. CofC.
InterProi IPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01983. CofC. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR03552. F420_cofC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB / ATCC 35089 / DSM 1224.

Entry informationi

Entry nameiCOFC_METVS
AccessioniPrimary (citable) accession number: A6URA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: August 21, 2007
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3