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A6URA0

- COFC_METVS

UniProt

A6URA0 - COFC_METVS

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Protein

2-phospho-L-lactate guanylyltransferase

Gene
cofC, Mevan_1122
Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor By similarity.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. nucleotidyltransferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN406327:GI04-1157-MONOMER.
UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferase (EC:2.7.7.68)
Short name:
LP guanylyltransferase
Gene namesi
Name:cofC
Ordered Locus Names:Mevan_1122
OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001107: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2242242-phospho-L-lactate guanylyltransferaseUniRule annotationPRO_0000398748Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi406327.Mevan_1122.

Structurei

3D structure databases

ProteinModelPortaliA6URA0.

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.

Phylogenomic databases

eggNOGiCOG1920.
HOGENOMiHOG000223639.
KOiK14941.
OMAiDLGEIFI.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

A6URA0-1 [UniParc]FASTAAdd to Basket

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MLAALIPVSP LSNVKSRLKE FLSSKERIDL IKNILLDTYE KVKSCVDACY    50
VVSKDDEILE FSKNLGIIPI KEDLNTKGLN EAIEYSLNII KEDSVLITPA 100
DVPLLKEENL ESIVKKSVEN SVIICPSRGG GTNLLLLNPK NCIKPQFEGF 150
SFLKHIKEAE INNLNIIKCH SFYTSIDINT VEDLGEIFIH GKDTKTYKFL 200
KNLNIEAFPK HSSAGRFNII RKSQ 224
Length:224
Mass (Da):25,209
Last modified:August 21, 2007 - v1
Checksum:i327C69B89D7C0FBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR55022.1.
RefSeqiWP_012065937.1. NC_009634.1.
YP_001323634.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR55022; ABR55022; Mevan_1122.
GeneIDi5326069.
KEGGimvn:Mevan_1122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR55022.1 .
RefSeqi WP_012065937.1. NC_009634.1.
YP_001323634.1. NC_009634.1.

3D structure databases

ProteinModelPortali A6URA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 406327.Mevan_1122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR55022 ; ABR55022 ; Mevan_1122 .
GeneIDi 5326069.
KEGGi mvn:Mevan_1122.

Phylogenomic databases

eggNOGi COG1920.
HOGENOMi HOG000223639.
KOi K14941.
OMAi DLGEIFI.

Enzyme and pathway databases

UniPathwayi UPA00071 .
BioCyci MVAN406327:GI04-1157-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
HAMAPi MF_02114. CofC.
InterProi IPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01983. CofC. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR03552. F420_cofC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB / ATCC 35089 / DSM 1224.

Entry informationi

Entry nameiCOFC_METVS
AccessioniPrimary (citable) accession number: A6URA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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