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A6URA0 (COFC_METVS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-phospho-L-lactate guanylyltransferase

Short name=LP guanylyltransferase
EC=2.7.7.68
Gene names
Name:cofC
Ordered Locus Names:Mevan_1122
OrganismMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]
Taxonomic identifier406327 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor By similarity. HAMAP-Rule MF_02114

Catalytic activity

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate. HAMAP-Rule MF_02114

Pathway

Cofactor biosynthesis; coenzyme F420 biosynthesis. HAMAP-Rule MF_02114

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_02114

Sequence similarities

Belongs to the CofC family.

Ontologies

Keywords
   LigandGTP-binding
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotidyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2242242-phospho-L-lactate guanylyltransferase HAMAP-Rule MF_02114
PRO_0000398748

Sequences

Sequence LengthMass (Da)Tools
A6URA0 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 327C69B89D7C0FBA

FASTA22425,209
        10         20         30         40         50         60 
MLAALIPVSP LSNVKSRLKE FLSSKERIDL IKNILLDTYE KVKSCVDACY VVSKDDEILE 

        70         80         90        100        110        120 
FSKNLGIIPI KEDLNTKGLN EAIEYSLNII KEDSVLITPA DVPLLKEENL ESIVKKSVEN 

       130        140        150        160        170        180 
SVIICPSRGG GTNLLLLNPK NCIKPQFEGF SFLKHIKEAE INNLNIIKCH SFYTSIDINT 

       190        200        210        220 
VEDLGEIFIH GKDTKTYKFL KNLNIEAFPK HSSAGRFNII RKSQ 

« Hide

References

[1]"Complete sequence of Methanococcus vannielii SB."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000742 Genomic DNA. Translation: ABR55022.1.
RefSeqYP_001323634.1. NC_009634.1.

3D structure databases

ProteinModelPortalA6URA0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING406327.Mevan_1122.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR55022; ABR55022; Mevan_1122.
GeneID5326069.
KEGGmvn:Mevan_1122.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1920.
HOGENOMHOG000223639.
KOK14941.
OMADLGEIFI.

Enzyme and pathway databases

BioCycMVAN406327:GI04-1157-MONOMER.
UniPathwayUPA00071.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
HAMAPMF_02114. CofC.
InterProIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
TIGRFAMsTIGR03552. F420_cofC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOFC_METVS
AccessionPrimary (citable) accession number: A6URA0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: August 21, 2007
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways