Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A6URA0

- COFC_METVS

UniProt

A6URA0 - COFC_METVS

Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

    Catalytic activityi

    (2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. nucleotidyltransferase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMVAN406327:GI04-1157-MONOMER.
    UniPathwayiUPA00071.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
    Short name:
    LP guanylyltransferaseUniRule annotation
    Gene namesi
    Name:cofCUniRule annotation
    Ordered Locus Names:Mevan_1122
    OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
    Taxonomic identifieri406327 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000001107: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2242242-phospho-L-lactate guanylyltransferasePRO_0000398748Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi406327.Mevan_1122.

    Structurei

    3D structure databases

    ProteinModelPortaliA6URA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CofC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1920.
    HOGENOMiHOG000223639.
    KOiK14941.
    OMAiDLGEIFI.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    HAMAPiMF_02114. CofC.
    InterProiIPR002835. Coenzyme_F420_CofC.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01983. CofC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6URA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAALIPVSP LSNVKSRLKE FLSSKERIDL IKNILLDTYE KVKSCVDACY    50
    VVSKDDEILE FSKNLGIIPI KEDLNTKGLN EAIEYSLNII KEDSVLITPA 100
    DVPLLKEENL ESIVKKSVEN SVIICPSRGG GTNLLLLNPK NCIKPQFEGF 150
    SFLKHIKEAE INNLNIIKCH SFYTSIDINT VEDLGEIFIH GKDTKTYKFL 200
    KNLNIEAFPK HSSAGRFNII RKSQ 224
    Length:224
    Mass (Da):25,209
    Last modified:August 21, 2007 - v1
    Checksum:i327C69B89D7C0FBA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000742 Genomic DNA. Translation: ABR55022.1.
    RefSeqiWP_012065937.1. NC_009634.1.
    YP_001323634.1. NC_009634.1.

    Genome annotation databases

    EnsemblBacteriaiABR55022; ABR55022; Mevan_1122.
    GeneIDi5326069.
    KEGGimvn:Mevan_1122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000742 Genomic DNA. Translation: ABR55022.1 .
    RefSeqi WP_012065937.1. NC_009634.1.
    YP_001323634.1. NC_009634.1.

    3D structure databases

    ProteinModelPortali A6URA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 406327.Mevan_1122.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR55022 ; ABR55022 ; Mevan_1122 .
    GeneIDi 5326069.
    KEGGi mvn:Mevan_1122.

    Phylogenomic databases

    eggNOGi COG1920.
    HOGENOMi HOG000223639.
    KOi K14941.
    OMAi DLGEIFI.

    Enzyme and pathway databases

    UniPathwayi UPA00071 .
    BioCyci MVAN406327:GI04-1157-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    HAMAPi MF_02114. CofC.
    InterProi IPR002835. Coenzyme_F420_CofC.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01983. CofC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR03552. F420_cofC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB / ATCC 35089 / DSM 1224.

    Entry informationi

    Entry nameiCOFC_METVS
    AccessioniPrimary (citable) accession number: A6URA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3