A6UR56 (ARGB_METVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Mevan_1078

Organism

Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]

Taxonomic identifier

406327 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_A
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_A
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_A.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Acetylglutamate kinase HAMAP MF_00082_A		PRO_1000010510
Regions
	Region	63 – 64	2	Substrate binding By similarity
Sites
	Binding site	85	1	Substrate By similarity
	Binding site	188	1	Substrate By similarity
	Site	28	1	Transition state stabilizer By similarity
	Site	251	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6UR56 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: B7E631B88041DED2	FASTA	294	32,489
	10 20 30 40 50 60 MDEYKKAEIL IEALPYICKF HDQKFVIKYG GHAMVNEQAK NWIAKDMVLL KYVGINPIIV 70 80 90 100 110 120 HGGGPEINRA MEKMGKVPEF IHGLRVTDEE TLEIVKMVLI GKINGDIVSK LEQYGGKSVG 130 140 150 160 170 180 LSGKSGQLIK ARKKIQYLIR DNEKIEVDLG MVGEVERVDT KLVDILVEKK YIPVISPIGV 190 200 210 220 230 240 DEQNKDLNLN ADIAAGDIAG AMNAEKLIMV TDVDGIMDDI NDPKTLHRKL TISQIEKMIE 250 260 270 280 290 KGIITGGMIP KIEACINALN KGVQSVHIVN GKIPHAVLLE IFTEEGIGTM ILKD

References

[1]

"Complete sequence of Methanococcus vannielii SB." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000742 Genomic DNA. Translation: ABR54978.1.
RefSeq	YP_001323590.1. NC_009634.1.
3D structure databases
ProteinModelPortal	A6UR56.
ModBase	Search...
Protein-protein interaction databases
STRING	A6UR56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5325321.
GenomeReviews	Gene locus Mevan_1078 in contig CP000742_GR.
KEGG	mvn:Mevan_1078.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04941.
HOGENOM	HBG497643.
OMA	GGNAMID.
ProtClustDB	PRK00942.
Family and domain databases
HAMAP	MF_00082_A. ArgB_A. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_METVS

Accession

Primary (citable) accession number: A6UR56

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program