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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei161May be catalytically importantUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciMVAN406327:G1G99-1064-MONOMER
UniPathwayiUPA00065

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:Mevan_1031
OrganismiMethanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000686681 – 312GTP cyclohydrolase MptAAdd BLAST312

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi406327.Mevan_1031

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301 Archaea
COG1469 LUCA
HOGENOMiHOG000280680
KOiK17488
OMAiHNQRGRG
OrthoDBiPOG093Z06SZ

Family and domain databases

HAMAPiMF_01527_A GTP_cyclohydrol_A, 1 hit
InterProiView protein in InterPro
IPR003801 GTP_cyclohydrolase_FolE2/MptA
IPR022840 GTP_cyclohydrolase_MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

A6UR12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCSDVQATE PDIKVSLTRV GVTNLKKLVK IKRKSKRDIV LLPTFEVYVD
60 70 80 90 100
LPSSQKGIHM SRSPEVIEEV VENIIVEKEI YGVEELSVEI VMKLFEKHEY
110 120 130 140 150
ATRAEVMLYS DYMMEEKSPV TKKDSQEVGK IMARAYGVKD DSGMISVKKM
160 170 180 190 200
VGAEVVGITA CPCAQNLLKE NAINKLIEKG FSNEDIEKIL DSVTIATHNQ
210 220 230 240 250
RGIGTIMIEV PNGYTVGISK IIKIIKESMS GEVYELLKRS DEAYVVELAH
260 270 280 290 300
KNPKFVEDCA REMIKRVVEV FDYLPEDTQV IVRQVNKESI HRHDAFAERK
310
SKMGELRDEL EI
Length:312
Mass (Da):35,385
Last modified:August 21, 2007 - v1
Checksum:i83C3D1D32D2045C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA Translation: ABR54934.1
RefSeqiWP_012065863.1, NC_009634.1

Genome annotation databases

EnsemblBacteriaiABR54934; ABR54934; Mevan_1031
GeneIDi5325493
KEGGimvn:Mevan_1031

Similar proteinsi

Entry informationi

Entry nameiMPTA_METVS
AccessioniPrimary (citable) accession number: A6UR12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health