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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei163GTPUniRule annotation1
Binding sitei167GTPUniRule annotation1
Binding sitei210GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 49GTPUniRule annotation5
Nucleotide bindingi132 – 134GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN406327:G1G99-766-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Mevan_0747Imported
OrganismiMethanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)Imported
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi406327.Mevan_0747

Structurei

3D structure databases

ProteinModelPortaliA6UQ81
SMRiA6UQ81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 228TubulinInterPro annotationAdd BLAST192
Domaini230 – 347Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6UQ81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLKNIAQT DFLDAAPEQI SDIDRELLEL IEQSKARITV IGCGGAGNNA
60 70 80 90 100
INRLLAESIS GARVIAINTD AQQLVKTHAD HKVLIGKNLT KGLGAGGNPV
110 120 130 140 150
KGEESAKENA EEIKKSIQDS DLVFITCGLG GGTGTGSAPV VAEISKKIGA
160 170 180 190 200
LTVAVVTLPF SMEGKVRMSN ALAGLNKLKE IADTIVIIPN DKLLEIVHNV
210 220 230 240 250
PLRTAFKVAD EVLMNSVRGM VELVNNAGDI HVDFADVRAV MNNGGIAMMG
260 270 280 290 300
IGESDSEKRA REAIQIALNS PLLCVDVDGA TGALIHITGP EDMSLDEAKE
310 320 330 340 350
IVSTVSDRLD DKATIIWGTT IDETLENSLR VLLIVTGTKS TGNYAIDTTK
360
KRYLIDIPKI
Length:360
Mass (Da):38,244
Last modified:August 21, 2007 - v1
Checksum:iF2014729EC6E3FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA Translation: ABR54653.1
RefSeqiWP_011972555.1, NC_009634.1

Genome annotation databases

EnsemblBacteriaiABR54653; ABR54653; Mevan_0747
GeneIDi5325471
KEGGimvn:Mevan_0747

Similar proteinsi

Entry informationi

Entry nameiA6UQ81_METVS
AccessioniPrimary (citable) accession number: A6UQ81
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health