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Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei132 – 133Important for bifunctional activityUniRule annotation2
Binding sitei135dCTPUniRule annotation1
Active sitei145Proton donor/acceptorUniRule annotation1
Binding sitei163dCTPUniRule annotation1
Binding sitei177dCTPUniRule annotation1
Binding sitei184dCTPUniRule annotation1
Binding sitei188dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi117 – 122dCTP bindingUniRule annotation6
Nucleotide bindingi143 – 145dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciMVAN406327:G1G99-756-MONOMER
UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:Mevan_0737
OrganismiMethanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001179851 – 206dCTP deaminase, dUMP-formingAdd BLAST206

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi406327.Mevan_0737

Structurei

3D structure databases

ProteinModelPortaliA6UQ71
SMRiA6UQ71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048 Archaea
COG0717 LUCA
HOGENOMiHOG000228601
KOiK09887
OMAiGWIDAGF
OrthoDBiPOG093Z0C6C

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

A6UQ71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDKDILN YVNSGRVCIN PFNRNFVGPC SYDVTLGEEF ITYNEDVYDV
60 70 80 90 100
KKQLSHRSFK IDNSIMVCPL HHHLDEKIIE RYKEKYSIDC VVSGGLLGTT
110 120 130 140 150
NEYVELPNDV CAQYQGRSSF GRVFLQSHQT AGWIDSGFKG KITLEIVAYD
160 170 180 190 200
KPVILYKNQR IGQLIFSKTL SPADIGYSDR KCSKYARQTS VMPSLIKKDF

ENDLEE
Length:206
Mass (Da):23,572
Last modified:August 21, 2007 - v1
Checksum:i64A2F96A8C3545B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA Translation: ABR54643.1
RefSeqiWP_011972545.1, NC_009634.1

Genome annotation databases

EnsemblBacteriaiABR54643; ABR54643; Mevan_0737
GeneIDi5325639
KEGGimvn:Mevan_0737

Entry informationi

Entry nameiDCDB_METVS
AccessioniPrimary (citable) accession number: A6UQ71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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