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A6UPX8 (AROC_METVS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Mevan_0644
OrganismMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]
Taxonomic identifier406327 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Chorismate synthase HAMAP MF_00300
PRO_1000022515

Sequences

Sequence LengthMass (Da)Tools
A6UPX8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 7F6F1586F2AC348B

FASTA37741,106
        10         20         30         40         50         60 
MLNTFGDTFR VTTWGESHGK ALGAVIDGCP SNLPLTENDI QYELNRRRPG YSLFSTPRKE 

        70         80         90        100        110        120 
EDEVEILSGI FEGKTTGTPI SCIVYNKSQQ SKDYTAIKDT PRPGHADLSY QLKYGNYDYR 

       130        140        150        160        170        180 
GGGRSSGRTT IGNVIGGAIA KKLIEYTHKI KVIGYTTEIG TIKGDFNYYN NPEFFESDLN 

       190        200        210        220        230        240 
IQKLSNQIED SVLRCPSTNS NEMNEYVFKA IDGKDSVGGV VEVVIYGLPK GIGNPIFNKL 

       250        260        270        280        290        300 
EGRLSSAVMS INSIKGFEVG KGFESSRLFG SEMNDEFYFK NGIICPKTNN AGGILGGIST 

       310        320        330        340        350        360 
GAPVVIRASI KPTPSISKTQ ETVNIKTLET VPIKIGGRHD PIIVPRVIPV IESMVSITIA 

       370 
DLMISSGFIN PSKLSNI

« Hide

References

[1]"Complete sequence of Methanococcus vannielii SB."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000742 Genomic DNA. Translation: ABR54550.1.
RefSeqYP_001323162.1. NC_009634.1.

3D structure databases

ProteinModelPortalA6UPX8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6UPX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5325272.
GenomeReviewsGene locus Mevan_0644 in contig CP000742_GR.
KEGGmvn:Mevan_0644.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04618.
HOGENOMHBG292336.
OMASRFTTQR.
ProtClustDBPRK05382.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_METVS
AccessionPrimary (citable) accession number: A6UPX8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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