A6UPQ6 (A6UPQ6_METVS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Mevan_0571

Organism

Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]

Taxonomic identifier

406327 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3 RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ABR54478.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	195	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	248	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	120	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	122	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	130	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	233	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	205	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	217	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	274	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	313	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A6UPQ6 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 9EBDDAC2659995C3	FASTA	322	35,754
	10 20 30 40 50 60 MIMRPRRLRK SEKIRNLVRE TTLTKNDLIM PIFIDENLNE NEKTPISSMP GQFRFGISAA 70 80 90 100 110 120 ILECIEISNL GVLAVILFGI PKEKDPFALS AFDENGGVQK VIRAVKKKLG DSLLVIADVC 130 140 150 160 170 180 MCEYTSHGHC GIVSNNEVLN DETLEVLADI ALSYAKAGVD IVAPSDMMDG RVLKIRKTLD 190 200 210 220 230 240 ENEFENVSIM SYAAKYASAF YGPFREAAES TPQFGDRKTY QMDSGNSREA LKEIQMDVLE 250 260 270 280 290 300 GADMILVKPA LSYLDIIKTA KENTLIPVGG YSVSGEYAMI ESAAEKGWID REKAIFEALL 310 320 SIKRAGADFI ITYWAKEISK KL

References

[1]

"Complete sequence of Methanococcus vannielii SB." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000742 Genomic DNA. Translation: ABR54478.1.
RefSeq	YP_001323090.1. NC_009634.1.
3D structure databases
ProteinModelPortal	A6UPQ6.
SMR	A6UPQ6. Positions 2-322.
ModBase	Search...
Protein-protein interaction databases
STRING	A6UPQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5326024.
GenomeReviews	Gene locus Mevan_0571 in contig CP000742_GR.
KEGG	mvn:Mevan_0571.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05029.
HOGENOM	HBG285270.
OMA	ADLCFCE.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A6UPQ6_METVS

Accession

Primary (citable) accession number: A6UPQ6

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)