A6UPQ3 (PUR5_METVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	Mevan_0568

Organism

Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]

Taxonomic identifier

406327 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_A
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_A
Subcellular location	Cytoplasm By similarity HAMAP MF_00741_A.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_A		PRO_1000046449

Sequences

	Sequence		Length	Mass (Da)
	A6UPQ3 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 9B4EECA43691A48D	FASTA	349	38,351
	10 20 30 40 50 60 MVTYKDAGVD IYEEDRIIRA LISKINFERE DAIKPADLKG HYAGAIEFGD YYLVLCTDGV 70 80 90 100 110 120 GSKMVVAEMA NNFETVPIDM IAMNVNDAIC IGAEPVALVD YMAVEEITEN IAEQIGKGLN 130 140 150 160 170 180 EGIKESNINL IGGETASLPN MIKGIDLAGT VLAVVKKSEI ISGQTVKKGD VIVGLRSSGI 190 200 210 220 230 240 HSNGLSLARK VFFEISNLNV NSKLSYGKTV ADELLTPTRI YVKPVLDMIK KADVKGLAHI 250 260 270 280 290 300 TGGGFRKLKR LNKEVCYKID NLPEIPPIFK EIQTLGNVAD EEMFKTFNMG IGFCVIVSKE 310 320 330 340 NAEKIIEISN QYKIPAFVIG EIEDNIEIDG EFKKETVLVE YNGKKMIME

References

[1]

"Complete sequence of Methanococcus vannielii SB." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000742 Genomic DNA. Translation: ABR54475.1.
RefSeq	YP_001323087.1. NC_009634.1.
3D structure databases
ProteinModelPortal	A6UPQ3.
ModBase	Search...
Protein-protein interaction databases
STRING	A6UPQ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5326015.
GenomeReviews	Gene locus Mevan_0568 in contig CP000742_GR.
KEGG	mvn:Mevan_0568.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04189.
HOGENOM	HBG531222.
OMA	DMYGADD.
ProtClustDB	PRK05385.
Family and domain databases
HAMAP	MF_00741_A. AIRS_A. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_METVS

Accession

Primary (citable) accession number: A6UPQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program