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A6UPQ3

- PUR5_METVS

UniProt

A6UPQ3 - PUR5_METVS

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN406327:GI04-573-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Mevan_0568
OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000001107: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000046449Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi406327.Mevan_0568.

Structurei

3D structure databases

ProteinModelPortaliA6UPQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiVIGKIEH.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UPQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTYKDAGVD IYEEDRIIRA LISKINFERE DAIKPADLKG HYAGAIEFGD
60 70 80 90 100
YYLVLCTDGV GSKMVVAEMA NNFETVPIDM IAMNVNDAIC IGAEPVALVD
110 120 130 140 150
YMAVEEITEN IAEQIGKGLN EGIKESNINL IGGETASLPN MIKGIDLAGT
160 170 180 190 200
VLAVVKKSEI ISGQTVKKGD VIVGLRSSGI HSNGLSLARK VFFEISNLNV
210 220 230 240 250
NSKLSYGKTV ADELLTPTRI YVKPVLDMIK KADVKGLAHI TGGGFRKLKR
260 270 280 290 300
LNKEVCYKID NLPEIPPIFK EIQTLGNVAD EEMFKTFNMG IGFCVIVSKE
310 320 330 340
NAEKIIEISN QYKIPAFVIG EIEDNIEIDG EFKKETVLVE YNGKKMIME
Length:349
Mass (Da):38,351
Last modified:August 21, 2007 - v1
Checksum:i9B4EECA43691A48D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR54475.1.
RefSeqiWP_011972378.1. NC_009634.1.
YP_001323087.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR54475; ABR54475; Mevan_0568.
GeneIDi5326015.
KEGGimvn:Mevan_0568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000742 Genomic DNA. Translation: ABR54475.1 .
RefSeqi WP_011972378.1. NC_009634.1.
YP_001323087.1. NC_009634.1.

3D structure databases

ProteinModelPortali A6UPQ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 406327.Mevan_0568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR54475 ; ABR54475 ; Mevan_0568 .
GeneIDi 5326015.
KEGGi mvn:Mevan_0568.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi VIGKIEH.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci MVAN406327:GI04-573-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB / ATCC 35089 / DSM 1224.

Entry informationi

Entry nameiPUR5_METVS
AccessioniPrimary (citable) accession number: A6UPQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3