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A6UPK5 (AROA_METVS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:Mevan_0520
OrganismMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]
Taxonomic identifier406327 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_0000325406

Sequences

Sequence LengthMass (Da)Tools
A6UPK5 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 03B7361F9B5366DB

FASTA42946,704
        10         20         30         40         50         60 
MLIVKRTSEV KGIINAPPSK SYTHRAVISA SLANGLSILK NPLNGADCLS SAHACRMLGA 

        70         80         90        100        110        120 
EITNEVEKWT IIGSKLKVPD NIIDIGNSGT TLRIITGISS QIPDGYAVIT GDDSIRKRPM 

       130        140        150        160        170        180 
QPLLDALKQL GIESFSTRNN GIAPIIVKAG KITSNSVKIR GDMSSQFITS LMMTLPFSET 

       190        200        210        220        230        240 
DSEIILTTPL KSEPYLNITI DVLDKFGVKI EKIVEENKTG YKIKGKQSYR PCEYTIEGDY 

       250        260        270        280        290        300 
SSASYLIATG VLLNSDIEVK NVFKNSKQGD REIIEIVKKM GADVEINENN VKIKGPYNLK 

       310        320        330        340        350        360 
GIEIDVTNIP DLVPTIAVLG CFAEGKTVVY NGEHVRLKEC DRLNACAVEL SKMGADIEEK 

       370        380        390        400        410        420 
PDGLIITGTH KLTGSKLKTH DDHRLVMAFT IAGMLADGET VIEGEESVKI SFPDFVDKMK 


SIGCNIEVI

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References

[1]"Complete sequence of Methanococcus vannielii SB."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000742 Genomic DNA. Translation: ABR54427.1.
RefSeqYP_001323039.1. NC_009634.1.

3D structure databases

ProteinModelPortalA6UPK5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6UPK5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5325721.
GenomeReviewsGene locus Mevan_0520 in contig CP000742_GR.
KEGGmvn:Mevan_0520.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG05032.
HOGENOMHBG646626.
OMARLRIKEC.
ProtClustDBPRK02427.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_METVS
AccessionPrimary (citable) accession number: A6UPK5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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