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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. Sirohydrochlorin cobaltochelatase (cbiX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) (cbiT)
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMVAN406327:G1G99-533-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Mevan_0518
OrganismiMethanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000468671 – 369Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST369

Proteomic databases

PRIDEiA6UPK3

Interactioni

Protein-protein interaction databases

STRINGi406327.Mevan_0518

Structurei

3D structure databases

ProteinModelPortaliA6UPK3
SMRiA6UPK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04383 Archaea
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG093Z05FA

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

A6UPK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDFRTETT FGYTTGACAV SGAYSALYFL KNNKKLDFVE ILNLKNETLI
60 70 80 90 100
IPIQNIERSE NTAFATVKKF SGKDIDITNN MTINVEVTLQ KLDNNSNLKL
110 120 130 140 150
IEIFGGNGVG IVTKRGLQID VGDYAINPKP REMIEKNLIS LLNDGEKAVV
160 170 180 190 200
RISIPNGDEI SKKTLNPKLG IIGGISILGT TGIVRPMSND AYKESLLPQI
210 220 230 240 250
DIAIQNGFEN LVFVPGNIGT KYAKSVLNIE EDQIIEVSNF WGFMLEKAGE
260 270 280 290 300
KGVKDITVFG HAGKIVKLAG GIFDTHSKVS DARNEILCAY TSTLCNNQEL
310 320 330 340 350
MKKILQSNTT EEIIEILAEK DILNEVFNLI SKRVVERLCL RFPNIKFSCI
360
IVDINGKILG KCFLGDRFD
Length:369
Mass (Da):40,822
Last modified:August 21, 2007 - v1
Checksum:i060DEEF14CB10DF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA Translation: ABR54425.1
RefSeqiWP_011972328.1, NC_009634.1

Genome annotation databases

EnsemblBacteriaiABR54425; ABR54425; Mevan_0518
GeneIDi5325708
KEGGimvn:Mevan_0518

Similar proteinsi

Entry informationi

Entry nameiCBID_METVS
AccessioniPrimary (citable) accession number: A6UPK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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