A6UPI8 (FUCA_METVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-fuculose phosphate aldolase
EC=4.1.2.17

Alternative name(s):
L-fuculose-1-phosphate aldolase

Gene names

Name:	fucA
Ordered Locus Names:	Mevan_0503

Organism

Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]

Taxonomic identifier

406327 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus vannielii

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible aldol cleavage of L-fuculose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde By similarity.
Catalytic activity	L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.
Cofactor	Binds 1 zinc ion per subunit Potential.
Pathway	Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3. Cofactor biosynthesis; coenzyme F420 biosynthesis.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the aldolase class II family. AraD/FucA subfamily.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fucose catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	L-fuculose-phosphate aldolase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	L-fuculose phosphate aldolase		PRO_0000342598
Sites
	Metal binding	68	1	Zinc By similarity
	Metal binding	87	1	Zinc By similarity
	Metal binding	89	1	Zinc By similarity
	Metal binding	147	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6UPI8 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 2DCDB963BE47E88D	FASTA	181	20,301
	10 20 30 40 50 60 MDLKEFIKIC HLLYDRKYVV GSGGNVSLKK DNLVYITPTG SILGFLNEED ICVVDIAGKI 70 80 90 100 110 120 IKGKPTSELN MHLEIYRNKP HVNAVVHTHS MYCTAFSVLD KKLELYTPEA EIFLKKIGYV 130 140 150 160 170 180 DYCPCGTLEL AECVSSCNED VLILKKHGIV TLGSTLTEAY IKTEVLEEIA KLNHIVMSFD K

References

[1]

"Complete sequence of Methanococcus vannielii SB." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. , Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000742 Genomic DNA. Translation: ABR54410.1.
RefSeq	YP_001323022.1. NC_009634.1.
3D structure databases
ProteinModelPortal	A6UPI8.
ModBase	Search...
Protein-protein interaction databases
STRING	406327.Mevan_0503.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR54410; ABR54410; Mevan_0503.
GeneID	5325627.
KEGG	mvn:Mevan_0503.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0235.
HOGENOM	HOG000218182.
KO	K01628.
OMA	STELRMH.
ProtClustDB	CLSK876567.
Enzyme and pathway databases
BioCyc	MVAN406327:GI04-554-MONOMER.
UniPathway	UPA00071. UPA00563; UER00626.
Family and domain databases
Gene3D	3.40.225.10. 1 hit.
InterPro	IPR001303. Aldolase_II/adducin_N. [Graphical view]
Pfam	PF00596. Aldolase_II. 1 hit. [Graphical view]
SMART	SM01007. Aldolase_II. 1 hit. [Graphical view]
SUPFAM	SSF53639. Aldolase_II_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUCA_METVS

Accession

Primary (citable) accession number: A6UPI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program