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A6UPI8 (FUCA_METVS) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-fuculose phosphate aldolase

EC=4.1.2.17
Alternative name(s):
L-fuculose-1-phosphate aldolase
Gene names
Name:fucA
Ordered Locus Names:Mevan_0503
OrganismMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]
Taxonomic identifier406327 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible aldol cleavage of L-fuculose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde By similarity.

Catalytic activity

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.

Cofactor

Binds 1 zinc ion per subunit Potential.

Pathway

Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3.

Cofactor biosynthesis; coenzyme F420 biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the aldolase class II family. AraD/FucA subfamily.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfucose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionL-fuculose-phosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181L-fuculose phosphate aldolase
PRO_0000342598

Sites

Metal binding681Zinc By similarity
Metal binding871Zinc By similarity
Metal binding891Zinc By similarity
Metal binding1471Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A6UPI8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 2DCDB963BE47E88D

FASTA18120,301
        10         20         30         40         50         60 
MDLKEFIKIC HLLYDRKYVV GSGGNVSLKK DNLVYITPTG SILGFLNEED ICVVDIAGKI 

        70         80         90        100        110        120 
IKGKPTSELN MHLEIYRNKP HVNAVVHTHS MYCTAFSVLD KKLELYTPEA EIFLKKIGYV 

       130        140        150        160        170        180 
DYCPCGTLEL AECVSSCNED VLILKKHGIV TLGSTLTEAY IKTEVLEEIA KLNHIVMSFD 


K 

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References

[1]"Complete sequence of Methanococcus vannielii SB."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000742 Genomic DNA. Translation: ABR54410.1.
RefSeqYP_001323022.1. NC_009634.1.

3D structure databases

ProteinModelPortalA6UPI8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING406327.Mevan_0503.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR54410; ABR54410; Mevan_0503.
GeneID5325627.
KEGGmvn:Mevan_0503.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0235.
HOGENOMHOG000218182.
KOK01628.
OMAEWRMHVA.
ProtClustDBCLSK876567.

Enzyme and pathway databases

BioCycMVAN406327:GI04-508-MONOMER.
UniPathwayUPA00071.
UPA00563; UER00626.

Family and domain databases

Gene3D3.40.225.10. 1 hit.
InterProIPR001303. Aldolase_II/adducin_N.
[Graphical view]
PfamPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMSSF53639. SSF53639. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFUCA_METVS
AccessionPrimary (citable) accession number: A6UPI8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 21, 2007
Last modified: October 16, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways