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A6UP37 (SYR_METVS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Mevan_0350
OrganismMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) [Complete proteome] [HAMAP]
Taxonomic identifier406327 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018067

Regions

Motif121 – 13111"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A6UP37 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 240BB70466A8A880

FASTA56964,914
        10         20         30         40         50         60 
MDVKKLIVVA IEKKVLDLTG KQIEIRLDEP PSINMGDYST NIAFRLSKEL KKAPKIIAEE 

        70         80         90        100        110        120 
ITSSLSIPGI EKIESLNGYI NFFMDYSVFS KETTLEINSK QENFGKSDLK NKKVILEHTS 

       130        140        150        160        170        180 
ANPNGPFHIG HGRNMVIGDS LKRILNAAGY TVETQYYVND MGRQEAIVVF GNDRFKLDKS 

       190        200        210        220        230        240 
KKSDHAIGQT YVEANKLLNE NEELEQEILN LMKNYEEAME NGIENEITEK FKNAVEYALT 

       250        260        270        280        290        300 
GFKETLSTLN IHHDKFVWES EFVRSGLVRN VINRLMETGK VTEEDVYRLD LSEFGIEKKL 

       310        320        330        340        350        360 
VLARLNGTSL YSTRDVAYHM TKMENCDFAV NLLGADHKLT GIMVNKTLAL LGYNEAEIVF 

       370        380        390        400        410        420 
YEFISLPEGS MSTRQGRFIS MDELFEEAKL RAREEVKKRE VAKTEEEIEE IAKKIAVGAV 

       430        440        450        460        470        480 
RYNIVRISPE KPMVFRWDEA LDFEKVGCPV IQYAHARCSR ILENCEPSGL VNSKNLFEYE 

       490        500        510        520        530        540 
MAENEKIIVK LISKLPEIVE KSAEVRKPQI LANYALELAQ GFNKFYGNCR ILKEENETVR 

       550        560 
NSRIMIVNST KLVLENSLDL LGIEMPGKM 

« Hide

References

[1]"Complete sequence of Methanococcus vannielii SB."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. expand/collapse author list , Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB / ATCC 35089 / DSM 1224.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000742 Genomic DNA. Translation: ABR54259.1.
RefSeqYP_001322871.1. NC_009634.1.

3D structure databases

ProteinModelPortalA6UP37.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING406327.Mevan_0350.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR54259; ABR54259; Mevan_0350.
GeneID5325871.
KEGGmvn:Mevan_0350.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMANPNGPLH.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycMVAN406327:GI04-354-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_METVS
AccessionPrimary (citable) accession number: A6UP37
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries