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A6UMM7 (A6UMM7_SINMW) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase PIRNR PIRNR000099
Short name=HDH PIRNR PIRNR000099
EC=1.1.1.23 PIRNR PIRNR000099
Gene names
Ordered Locus Names:Smed_6310
Encoded onPlasmid pSMED02 EMBL ABR64907.1
OrganismSinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]
Taxonomic identifier366394 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. PIRNR PIRNR000099 SAAS SAAS001692

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. PIRNR PIRNR000099 SAAS SAAS001692

Cofactor

Binds 1 zinc ion per subunit By similarity. SAAS SAAS001692

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. PIRNR PIRNR000099 SAAS SAAS001692

Sequence similarities

Belongs to the histidinol dehydrogenase family. PIRNR PIRNR000099 RuleBase RU004175

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3331Proton acceptor By similarity PIRSR PIRSR000099-1
Active site3341Proton acceptor By similarity PIRSR PIRSR000099-1

Sequences

Sequence LengthMass (Da)Tools
A6UMM7 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 38D5A9142111D0F6

FASTA44246,934
        10         20         30         40         50         60 
MTSVSFYEYS KLNDEEKAAL LRRSETDISG FIEKVAPILE AVRTEGDKAL ARFGRELDKA 

        70         80         90        100        110        120 
DVTEANLKVT AAEFDAAFKL VDASVVESVQ FGIDNIRKFH EEQKPEAMWL KEIRPGAFAG 

       130        140        150        160        170        180 
DRFTPIQSVA LYVPRGKGSF PSVTMMTSVP AVVAGVPNLA IVTPPAPDGS VDAATLVAAR 

       190        200        210        220        230        240 
LAGVETVYKA GGAQAVAAVA YGTETVKPAL KIVGPGSPWV VAAKRSLAGV IDTGLPAGPS 

       250        260        270        280        290        300 
EVMILADDTV HGGLAALDLL IEAEHGPDSS AYLVTHSRRV AEEALAALPE HGAKMTEQRV 

       310        320        330        340        350        360 
AFSKAVLTGK TGGIVLTSSI EESYAFVNAY APEHLELLSE QPFIHLGHIT EAAEILMGTH 

       370        380        390        400        410        420 
TPVSIANFSL GPNAVLPTSR WARTFGPLSV TDFVKRSSIG YVTAPAYPEF ARHSHNLAIY 

       430        440 
EGFSSHALAV SPVRDAYLKR GD

« Hide

References

[1]"Complete sequence of Sinorhizobium medicae WSM419 plasmid pSMED02."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM419.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000740 Genomic DNA. Translation: ABR64907.1.
RefSeqYP_001314840.1. NC_009621.1.

3D structure databases

ProteinModelPortalA6UMM7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6UMM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5320612.
GenomeReviewsGene locus Smed_6310 in contig CP000740_GR.
KEGGsmd:Smed_6310.
PATRIC23618321. VBISinMed134228_2833.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHBG329596.
OMAKIVGPGS.
ProtClustDBPRK12447.

Enzyme and pathway databases

BioCycSMED366394:SMED_6310-MONOMER.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
KOK00013.
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00069. HisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6UMM7_SINMW
AccessionPrimary (citable) accession number: A6UMM7
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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