ID   A6UMH0_SINMW            Unreviewed;       487 AA.
AC   A6UMH0;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:ABR64850.1};
GN   OrderedLocusNames=Smed_6251 {ECO:0000313|EMBL:ABR64850.1};
OS   Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OG   Plasmid pSMED02 {ECO:0000313|EMBL:ABR64850.1,
OG   ECO:0000313|Proteomes:UP000001108}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=366394 {ECO:0000313|EMBL:ABR64850.1, ECO:0000313|Proteomes:UP000001108};
RN   [1] {ECO:0000313|Proteomes:UP000001108}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM419 {ECO:0000313|Proteomes:UP000001108};
RC   PLASMID=Plasmid pSMED02 {ECO:0000313|Proteomes:UP000001108};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA   Richardson P.;
RT   "Complete sequence of Sinorhizobium medicae WSM419 plasmid pSMED02.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABR64850.1, ECO:0000313|Proteomes:UP000001108}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM419 {ECO:0000313|EMBL:ABR64850.1,
RC   ECO:0000313|Proteomes:UP000001108};
RC   PLASMID=Plasmid pSMED02 {ECO:0000313|Proteomes:UP000001108};
RX   PubMed=21304680; DOI=10.4056/sigs.43526;
RA   Reeve W., Chain P., O'Hara G., Ardley J., Nandesena K., Brau L., Tiwari R.,
RA   Malfatti S., Kiss H., Lapidus A., Copeland A., Nolan M., Land M.,
RA   Hauser L., Chang Y.J., Ivanova N., Mavromatis K., Markowitz V.,
RA   Kyrpides N., Gollagher M., Yates R., Dilworth M., Howieson J.;
RT   "Complete genome sequence of the Medicago microsymbiont Ensifer
RT   (Sinorhizobium) medicae strain WSM419.";
RL   Stand. Genomic Sci. 2:77-86(2010).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000740; ABR64850.1; -; Genomic_DNA.
DR   RefSeq; WP_011970937.1; NC_009621.1.
DR   RefSeq; YP_001314783.1; NC_009621.1.
DR   AlphaFoldDB; A6UMH0; -.
DR   KEGG; smd:Smed_6251; -.
DR   PATRIC; fig|366394.8.peg.2769; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_0_5; -.
DR   OrthoDB; 8175464at2; -.
DR   Proteomes; UP000001108; Plasmid pSMED02.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07114; ALDH_DhaS; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}; Plasmid {ECO:0000313|EMBL:ABR64850.1}.
FT   DOMAIN          16..471
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        248
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   487 AA;  52189 MW;  0AD5992C8185835D CRC64;
     MQRFQCYING EFADGEARFE SIDPTTGRAW AEMPEAREAD VNRAVEAARI ALHDQSWSTL
     TATQRGKLLY KLADLVAENA GRLAELETRD TGKIIRETSS QIAYVADYYR YYAGIADKIE
     GSYLPIDKPD MDVWLRREPI GVVAMVVPWN SQLFLSAVKI GPALAAGCTM VVKASEDGPA
     PLLEFARLVH AAGFPAGVVN IVTGFGPSCG AALSRHPQVD HIAFTGGPET ARHIVRNSAE
     NLASTSLELG GKSPFIVFAD ADLESAANAQ IAGIFAATGQ SCVAGSRLIV EKSVKDRFLQ
     ILKAKAETIR IGSPLEMSTE VGPLATERQC NHVKALIARS LAAGAKLVTG GTAPEGTGFY
     YRPTILDCDG SASPSLENEF FGPVLSVLSF ETEAEALHLA NGSRFGLAAG VFTQNLTRAH
     RLMKGIRAGI VWVNTYRAVS PVAPFGGFGL SGHGREGGLE AALDYTRSKT VWLRTSDDPI
     PDPFVMR
//