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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Smed_3536
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001108 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21
Transmembranei43 – 63HelicalUniRule annotationAdd BLAST21
Transmembranei84 – 104HelicalUniRule annotationAdd BLAST21
Transmembranei109 – 129HelicalUniRule annotationAdd BLAST21
Transmembranei184 – 204HelicalUniRule annotationAdd BLAST21
Transmembranei213 – 233HelicalUniRule annotationAdd BLAST21
Transmembranei248 – 268HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000628151 – 268Undecaprenyl-diphosphataseAdd BLAST268

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_3536.

Structurei

3D structure databases

SMRiA6UFC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218356.
KOiK06153.
OMAiPDARMGW.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiView protein in InterPro
IPR003824. UppP.
PANTHERiPTHR30622. PTHR30622. 1 hit.
PfamiView protein in Pfam
PF02673. BacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UFC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQSIISAL VLGLIEGLTE FIPVSSTAHV LLAGHFLGFR SPGNTFAVLI
60 70 80 90 100
QLGAILAILL VYFQKLLSIA LALPTSVRAR RFVLSVLLAF LPAALIGAAA
110 120 130 140 150
HGFIKSVLFE TPMLICVVLI VGGIILYVID RLPLTPRYTD VFDYPPSLAL
160 170 180 190 200
KIGLFQCLAM IPGTSRSGAT IAGALLMGTD KRSAAEFSFF LAMPTMVGAF
210 220 230 240 250
ALDLYKNREA LSIDDIGLIA AGFIAAFIAG IFVVRSLLDF VSHRGFTPFA
260
IWRILVGTAG LVGLWLLG
Length:268
Mass (Da):28,539
Last modified:August 21, 2007 - v1
Checksum:iA68B651FD63F26F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000738 Genomic DNA. Translation: ABR62352.1.
RefSeqiWP_012067731.1. NC_009636.1.
YP_001329187.1. NC_009636.1.

Genome annotation databases

EnsemblBacteriaiABR62352; ABR62352; Smed_3536.
GeneIDi5324424.
KEGGismd:Smed_3536.
PATRICifig|366394.8.peg.6788.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUPPP_SINMW
AccessioniPrimary (citable) accession number: A6UFC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families