A6UF08 (A6UF08_SINMW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 2 HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase 2 HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2 HAMAP MF_01401

Gene names

Name:	msrA2 HAMAP MF_01401
Ordered Locus Names:	Smed_3417

Organism

Sinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]

Taxonomic identifier

366394 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 SAAS SAAS002569 EMBL ABR62238.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	57	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	A6UF08 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 67D71FE450A4182A	FASTA	217	23,942
	10 20 30 40 50 60 MFLIDMFNKK TILPDAATAL AGREGEISTA ADHFVSGRPL KGPYPDGMKK VLFGMGCFWG 70 80 90 100 110 120 AERLLWEIPG VYVTAAGYSG GLTPNPTYQE TTTGLTGHTE VVLVVYDPAR VSFQRLLKTF 130 140 150 160 170 180 FEEHDPTQGM RQGNDVGTTY RSAIYVYDEE QLAEANAARN AFRKALKAYK HDREITTEIA 190 200 210 MAGPFYFAEE YHQQYLAKNP DGYCGLRGTG VSCPIGA

References

[1]

"Complete sequence of Sinorhizobium medicae WSM419 chromosome." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WSM419.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000738 Genomic DNA. Translation: ABR62238.1.
RefSeq	YP_001329073.1. NC_009636.1.
3D structure databases
ProteinModelPortal	A6UF08.
SMR	A6UF08. Positions 6-217.
ModBase	Search...
Protein-protein interaction databases
STRING	A6UF08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5324301.
GenomeReviews	Gene locus Smed_3417 in contig CP000738_GR.
KEGG	smd:Smed_3417.
PATRIC	23626107. VBISinMed134228_6665.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	QETSFEQ.
ProtClustDB	PRK00058.
Enzyme and pathway databases
BioCyc	SMED366394:SMED_3417-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6UF08_SINMW

Accession

Primary (citable) accession number: A6UF08

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)