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A6UET5 (ADE_SINMW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2
Alternative name(s):
Adenine aminohydrolase
Short name=AAH
Gene names
Ordered Locus Names:Smed_3344
OrganismSinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]
Taxonomic identifier366394 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Adenine deaminase HAMAP MF_01962
PRO_1000017708

Sites

Active site1921Proton donor By similarity
Metal binding111Zinc; catalytic By similarity
Metal binding131Zinc; catalytic By similarity
Metal binding1891Zinc; catalytic By similarity
Metal binding2701Zinc; catalytic By similarity
Binding site2711Substrate By similarity
Site2131Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A6UET5 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: D6D3242CE51656E4

FASTA32435,291
        10         20         30         40         50         60 
MTAHLKKAEL HCHIEGATPP ELAVRQARKY GVDTGTIIRD GAYVWEDFTS FVKCYDAVAS 

        70         80         90        100        110        120 
LFRTEGDYAL LAEAYLTELA EAGTIYSEII VSPDHGNTVG LGADAYLEGL AAGMEAAKAR 

       130        140        150        160        170        180 
KGIESRMLIT GIRHLGPEAV VRTAEYAASH RHPLVTGFNL AGEERMHSVA EFSRAFDIVR 

       190        200        210        220        230        240 
DAGLGLTIHA GELSGAFSVR DALDHVRPAR ISHGVRAIED TDLVRRLADE GVVLEVCPGS 

       250        260        270        280        290        300 
NIALKVFPDF PSHPLRRLYD AGVRVTLNSD DPPFFHTSLA QEYEIAAHAM GFSDGEIDRM 

       310        320 
TRTALEAAFV DEPTRERLLA ALHI

« Hide

References

[1]"Complete sequence of Sinorhizobium medicae WSM419 chromosome."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM419.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000738 Genomic DNA. Translation: ABR62165.1.
RefSeqYP_001329000.1. NC_009636.1.

3D structure databases

ProteinModelPortalA6UET5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6UET5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5324228.
GenomeReviewsGene locus Smed_3344 in contig CP000738_GR.
KEGGsmd:Smed_3344.
PATRIC23625957. VBISinMed134228_6590.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1816.
HOGENOMHBG630382.
OMAIVLECCP.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycSMED366394:SMED_3344-MONOMER.

Family and domain databases

HAMAPMF_01962. Adenine_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADE_SINMW
AccessionPrimary (citable) accession number: A6UET5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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