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A6UET3 (TYPH_SINMW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:Smed_3342
OrganismSinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]
Taxonomic identifier366394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_1000069677

Sequences

Sequence LengthMass (Da)Tools
A6UET3 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 2421291204D24E2F

FASTA43845,990
        10         20         30         40         50         60 
MAMLPQEVIR KKRDGGRLVP AEIAGFIEGL ADGSISEGQA AAFAMAVWFS GMSRDECVAL 

        70         80         90        100        110        120 
TLAMRDSGET LDWGEFGRPV VDKHSTGGVG DNVSLMLAPI VAACGPVVPM ISGRGLGHTG 

       130        140        150        160        170        180 
GTLDKLESIP GYNIQPSPEL FRRVVDEVGC AIIGQTANLA PADKRLYAIR DVTATVDSVP 

       190        200        210        220        230        240 
LITASILSKK LAAGLQSLVL DVKLGNGSFM TDPAETEILA RSLVEVANGA GVRTSALITD 

       250        260        270        280        290        300 
MNEPLADAAG NALEVENCLA YLSGKKAGTR LDRVVMAFAA EMLAAAGVSA HKAEGEAMAR 

       310        320        330        340        350        360 
RALESGEALE RFGLMVHRLG GPADFVERPE AYLERAPAIV PVAAARDGYL AACETRELGM 

       370        380        390        400        410        420 
AVIALGGGRR RPDDRIDHRV GLAGLRPLRT KVEKGEPIAF VHGADRDQAE AVAKRVATLY 

       430 
AIAEEAPAQR PVIASRLV 

« Hide

References

[1]"Complete sequence of Sinorhizobium medicae WSM419 chromosome."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM419.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000738 Genomic DNA. Translation: ABR62163.1.
RefSeqYP_001328998.1. NC_009636.1.

3D structure databases

ProteinModelPortalA6UET3.
SMRA6UET3. Positions 3-437.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING366394.Smed_3342.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR62163; ABR62163; Smed_3342.
GeneID5324226.
KEGGsmd:Smed_3342.
PATRIC23625953. VBISinMed134228_6588.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMACGLAVPM.
OrthoDBEOG61ZTGG.
ProtClustDBPRK05820.

Enzyme and pathway databases

BioCycSMED366394:GJAL-3399-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_SINMW
AccessionPrimary (citable) accession number: A6UET3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways