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Protein

Acid tolerance regulatory protein ActR

Gene

actR

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-56-MONOMER.
SMED366394:GJAL-3325-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid tolerance regulatory protein ActR
Gene namesi
Name:actR
Ordered Locus Names:Smed_3273
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001108 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Acid tolerance regulatory protein ActRPRO_0000310444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei73 – 7314-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by ActS.Curated

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_3273.

Structurei

3D structure databases

ProteinModelPortaliA6UEL7.
SMRiA6UEL7. Positions 144-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 138115Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UYB. Bacteria.
COG4567. LUCA.
HOGENOMiHOG000034817.
KOiK15012.
OMAiAIRQRRD.
OrthoDBiPOG091H1BVE.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6UEL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEKSTPAPI THAADADLIG PDKSLLIVDD DTAFLRRLAR AMEARGFAVE
60 70 80 90 100
IAESVAEGIA KAKTRPPKHA VIDLRLGDGS GLDVIEAIRG RRDDTRMIVL
110 120 130 140 150
TGYGNIATAV NAVKLGALDY LAKPADADDI LAALIQRPGE RVEPPENPMS
160 170 180 190
ADRVRWEHIQ RVYEMCERNV SETARRLNMH RRTLQRILAK RAPK
Length:194
Mass (Da):21,421
Last modified:August 21, 2007 - v1
Checksum:i9BD60917F815CB4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39938 Genomic DNA. Translation: AAB38421.2.
CP000738 Genomic DNA. Translation: ABR62097.1.
RefSeqiWP_012067478.1. NC_009636.1.
YP_001328932.1. NC_009636.1.

Genome annotation databases

EnsemblBacteriaiABR62097; ABR62097; Smed_3273.
GeneIDi5324152.
KEGGismd:Smed_3273.
PATRICi23625793. VBISinMed134228_6514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39938 Genomic DNA. Translation: AAB38421.2.
CP000738 Genomic DNA. Translation: ABR62097.1.
RefSeqiWP_012067478.1. NC_009636.1.
YP_001328932.1. NC_009636.1.

3D structure databases

ProteinModelPortaliA6UEL7.
SMRiA6UEL7. Positions 144-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi366394.Smed_3273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR62097; ABR62097; Smed_3273.
GeneIDi5324152.
KEGGismd:Smed_3273.
PATRICi23625793. VBISinMed134228_6514.

Phylogenomic databases

eggNOGiENOG4108UYB. Bacteria.
COG4567. LUCA.
HOGENOMiHOG000034817.
KOiK15012.
OMAiAIRQRRD.
OrthoDBiPOG091H1BVE.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-56-MONOMER.
SMED366394:GJAL-3325-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACTR_SINMW
AccessioniPrimary (citable) accession number: A6UEL7
Secondary accession number(s): Q52913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.