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A6UEK2

- HIS2_SINMW

UniProt

A6UEK2 - HIS2_SINMW

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Protein

Phosphoribosyl-ATP pyrophosphatase

Gene

hisE

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosyl-ATP diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMED366394:GJAL-3310-MONOMER.
UniPathwayiUPA00031; UER00007.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
Short name:
PRA-PHUniRule annotation
Gene namesi
Name:hisEUniRule annotation
Ordered Locus Names:Smed_3258
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001108: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Phosphoribosyl-ATP pyrophosphatasePRO_1000063384Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_3258.

Structurei

3D structure databases

ProteinModelPortaliA6UEK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-PH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0140.
HOGENOMiHOG000220965.
KOiK01523.
OMAiPEKCAEK.
OrthoDBiEOG6CGCMH.

Family and domain databases

HAMAPiMF_01020. HisE.
InterProiIPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
[Graphical view]
PfamiPF01503. PRA-PH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UEK2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEFTLSDLE KIVATRARAA PEESWTAKLV AAGQKKAAKK LGEEAVETVI
60 70 80 90 100
AAIGDDRKNL VDESADLLYH LMVVLNIAAI PLQDVMSELA RRTSQSGLQE

KANRQNP
Length:107
Mass (Da):11,660
Last modified:August 21, 2007 - v1
Checksum:i0517AE382703FC91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000738 Genomic DNA. Translation: ABR62082.1.
RefSeqiYP_001328917.1. NC_009636.1.

Genome annotation databases

EnsemblBacteriaiABR62082; ABR62082; Smed_3258.
GeneIDi5324137.
KEGGismd:Smed_3258.
PATRICi23625761. VBISinMed134228_6498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000738 Genomic DNA. Translation: ABR62082.1 .
RefSeqi YP_001328917.1. NC_009636.1.

3D structure databases

ProteinModelPortali A6UEK2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366394.Smed_3258.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR62082 ; ABR62082 ; Smed_3258 .
GeneIDi 5324137.
KEGGi smd:Smed_3258.
PATRICi 23625761. VBISinMed134228_6498.

Phylogenomic databases

eggNOGi COG0140.
HOGENOMi HOG000220965.
KOi K01523.
OMAi PEKCAEK.
OrthoDBi EOG6CGCMH.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00007 .
BioCyci SMED366394:GJAL-3310-MONOMER.

Family and domain databases

HAMAPi MF_01020. HisE.
InterProi IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
[Graphical view ]
Pfami PF01503. PRA-PH. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03188. histidine_hisI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM419.

Entry informationi

Entry nameiHIS2_SINMW
AccessioniPrimary (citable) accession number: A6UEK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3