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A6UEG4 (A6UEG4_SINMW) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit B RuleBase RU003363 HAMAP MF_01898
EC=5.99.1.3 RuleBase RU003363 HAMAP MF_01898
Gene names
Name:gyrB HAMAP MF_01898
Ordered Locus Names:Smed_3220
OrganismSinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]
Taxonomic identifier366394 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length811 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. RuleBase RU003363 HAMAP MF_01898

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. RuleBase RU003363 SAAS SAAS002288 HAMAP MF_01898

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01898

Subcellular location

Cytoplasm By similarity HAMAP MF_01898.

Sequence similarities

Belongs to the type II topoisomerase family. HAMAP MF_01898 RuleBase RU000380

Contains 1 Toprim domain. SAAS SAAS002288 HAMAP MF_01898

Sequences

Sequence LengthMass (Da)Tools
A6UEG4 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: E7ED81C56701022E

FASTA81188,837
        10         20         30         40         50         60 
MTEISETEAG AIAEYGADSI KVLKGLDAVR KRPGMYIGDT DDGSGLHHMV YEVVDNAIDE 

        70         80         90        100        110        120 
ALAGHADLVT VTLNPDGSVT VTDNGRGIPT DIHREEGVSA AEVIMTQLHA GGKFDQNSYK 

       130        140        150        160        170        180 
VSGGLHGVGV SVVNALSVSL KLKIRRSGKI HEMSFTHGVA DGPLKVTGDA GSDTGTEVTF 

       190        200        210        220        230        240 
TPSEQTFSNI EFEFARLEHR LRELAFLNSG VRIVLTDKRH SDIRREELMY DGGLEAFVAY 

       250        260        270        280        290        300 
LDRAKKPLVQ KPVSIRGEKD GITVEVAMWW NDSYHENMLC FTNNIPQRDG GTHMAGFRAA 

       310        320        330        340        350        360 
LTRQITSYAD SSGVTKKEKV SLTGDDCREG LTAVLSVKVP DPKFSSQTKD KLVSSEVRPV 

       370        380        390        400        410        420 
VESLVNEALG VWLEEHPSDA KILVGKVVEA AAAREAARKA RELTRRKGAL DISSLPGKLA 

       430        440        450        460        470        480 
DCSERDPAKS ELFLVEGDSA GGSAKQGRSR ESQAILPLRG KILNVERARF DKMLSSQEIG 

       490        500        510        520        530        540 
TLITALGTSI GPDEFNADKL RYHKIIIMTD ADVDGAHIRT LLLTFFFRQM PVLIERGHLY 

       550        560        570        580        590        600 
IAQPPLYKVA RGKSVQYLKD EKALEDYLIN MGLEEASLEL ASGEVRAGQD LREVINDALR 

       610        620        630        640        650        660 
LRSLMDGLHS RYNRSVVEQA AIAGALNVEL NGQRNEYQQI AAEVARRLDV IAEETERGWA 

       670        680        690        700        710        720 
AEVTAEGGLK LERMVRGVKE AAVLDMALIG SSDARHIDQL KSRLKEVYGA PPMLRRRDGT 

       730        740        750        760        770        780 
QEISGPRALL DAIFAAGRKG LTMQRYKGLG EMNAEQLWET TLDPNVRSLL QVKVNDATDA 

       790        800        810 
DGLFSRLMGD EVEPRRDFIQ ENALSVANLD I

« Hide

References

[1]"Complete sequence of Sinorhizobium medicae WSM419 chromosome."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM419.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000738 Genomic DNA. Translation: ABR62044.1.
RefSeqYP_001328879.1. NC_009636.1.

3D structure databases

ProteinModelPortalA6UEG4.
SMRA6UEG4. Positions 20-389.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6UEG4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5324099.
GenomeReviewsGene locus Smed_3220 in contig CP000738_GR.
KEGGsmd:Smed_3220.
PATRIC23625681. VBISinMed134228_6458.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0187.
HOGENOMHBG304889.
OMADCSSRDP.
ProtClustDBPRK14939.

Enzyme and pathway databases

BioCycSMED366394:SMED_3220-MONOMER.

Family and domain databases

HAMAPMF_01898. GyrB.
[Tree]
InterProIPR003594. ATPase-like_ATP-bd.
IPR011557. GyrB.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013759. Topo_IIA_B/N_ab.
IPR002288. Topo_IIA_B_C.
IPR013506. Topo_IIA_bsu_dom2.
IPR013760. Topo_IIA_cen.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
G3DSA:3.40.50.670. Topo_IIA_B/N_ab. 2 hits.
KOK02470.
PfamPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSPR00418. TPI2FAMILY.
SMARTSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMSSF55874. ATP_bd_ATPase. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01059. GyrB. 1 hit.
PROSITEPS00177. TOPOISOMERASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6UEG4_SINMW
AccessionPrimary (citable) accession number: A6UEG4
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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