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A6UEE2

- SYL_SINMW

UniProt

A6UEE2 - SYL_SINMW

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei635 – 6351ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMED366394:GJAL-3250-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Smed_3198
    OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
    Taxonomic identifieri366394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001108: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 876876Leucine--tRNA ligasePRO_1000009434Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi366394.Smed_3198.

    Structurei

    3D structure databases

    ProteinModelPortaliA6UEE2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi632 – 6365"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6UEE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATERYNPRD AEPRWQQQWE AGKIFETKND DPREKYYVLE MFPYPSGRIH    50
    MGHVRNYTMG DVVARYKRAR GFNVLHPMGW DAFGMPAENA AMERGVHPAS 100
    WTYQNIASMK AQLKVMGLSL DWSREFATCD PEYYQRQQHL FLDFLEKGLV 150
    YRKQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFRITDFS 200
    QDLLDSLDTL DEWPEKVRLM QKNWIGRSEG LSVRWELDPA TVPGEEKELT 250
    VYTTRPDTLF GASFLAISAD HPLARDAAAK SAEIEAFCEE CRRAGTSLAA 300
    LETAEKMGID TGIRARHPFD PDWELPVYVA NFVLMDYGTG AIFGCPSGDQ 350
    RDLDFARKYG LPVVPVVMPK DADPQTFTIG DEAYVGDGVM INSRFLDGLS 400
    TEEAFETIAT RLEKDLLNGT PRAERKVNFR LRDWGISRQR YWGCPIPVIH 450
    CDDCGVVPVP KTDLPVTLPP DVTFDKPGNP LDRHPTWRHV ACPQCGKDAR 500
    RETDTMDTFV DSSWYFTRFT APWEDGPTDP KAANHWLPVD QYIGGIEHAI 550
    LHLLYSRFFT RAMKATGHVA LDEPFKGLFT QGMVVHETYS RGEGAQREWI 600
    TPAEIRIEEA DGQRRAVHIE TSEEIAIGSI EKMSKSKKNV VDPDDIIASY 650
    GADTARFFVL SDSPPDRDVI WSEAGVEGAH RFVQRVWRLL SEAAEGLSAA 700
    EAAPAREGEG LAVSQAAHRT LKAVEADYDK LAFNKAVARI YELVNTLAAP 750
    LAQIAAGKAD QALTAAVKDA AGILISLIAP MMPHLAEECW RAIGGKGLIA 800
    ERPWPKFDAT LVVENEITLP VQINGKKRAD LTIARDADQS AIESAVLALD 850
    VVKTALNGSN PKKIIVVPQR IVNVVV 876
    Length:876
    Mass (Da):98,092
    Last modified:August 21, 2007 - v1
    Checksum:i4AF876E12CEFBBBC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR62022.1.
    RefSeqiYP_001328857.1. NC_009636.1.

    Genome annotation databases

    EnsemblBacteriaiABR62022; ABR62022; Smed_3198.
    GeneIDi5324077.
    KEGGismd:Smed_3198.
    PATRICi23625637. VBISinMed134228_6436.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR62022.1 .
    RefSeqi YP_001328857.1. NC_009636.1.

    3D structure databases

    ProteinModelPortali A6UEE2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 366394.Smed_3198.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR62022 ; ABR62022 ; Smed_3198 .
    GeneIDi 5324077.
    KEGGi smd:Smed_3198.
    PATRICi 23625637. VBISinMed134228_6436.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SMED366394:GJAL-3250-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WSM419.

    Entry informationi

    Entry nameiSYL_SINMW
    AccessioniPrimary (citable) accession number: A6UEE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3