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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei635ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Smed_3198
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001108 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094341 – 876Leucine--tRNA ligaseAdd BLAST876

Proteomic databases

PRIDEiA6UEE2

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_3198

Structurei

3D structure databases

ProteinModelPortaliA6UEE2
SMRiA6UEE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi632 – 636"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A6UEE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATERYNPRD AEPRWQQQWE AGKIFETKND DPREKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYTMG DVVARYKRAR GFNVLHPMGW DAFGMPAENA AMERGVHPAS
110 120 130 140 150
WTYQNIASMK AQLKVMGLSL DWSREFATCD PEYYQRQQHL FLDFLEKGLV
160 170 180 190 200
YRKQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFRITDFS
210 220 230 240 250
QDLLDSLDTL DEWPEKVRLM QKNWIGRSEG LSVRWELDPA TVPGEEKELT
260 270 280 290 300
VYTTRPDTLF GASFLAISAD HPLARDAAAK SAEIEAFCEE CRRAGTSLAA
310 320 330 340 350
LETAEKMGID TGIRARHPFD PDWELPVYVA NFVLMDYGTG AIFGCPSGDQ
360 370 380 390 400
RDLDFARKYG LPVVPVVMPK DADPQTFTIG DEAYVGDGVM INSRFLDGLS
410 420 430 440 450
TEEAFETIAT RLEKDLLNGT PRAERKVNFR LRDWGISRQR YWGCPIPVIH
460 470 480 490 500
CDDCGVVPVP KTDLPVTLPP DVTFDKPGNP LDRHPTWRHV ACPQCGKDAR
510 520 530 540 550
RETDTMDTFV DSSWYFTRFT APWEDGPTDP KAANHWLPVD QYIGGIEHAI
560 570 580 590 600
LHLLYSRFFT RAMKATGHVA LDEPFKGLFT QGMVVHETYS RGEGAQREWI
610 620 630 640 650
TPAEIRIEEA DGQRRAVHIE TSEEIAIGSI EKMSKSKKNV VDPDDIIASY
660 670 680 690 700
GADTARFFVL SDSPPDRDVI WSEAGVEGAH RFVQRVWRLL SEAAEGLSAA
710 720 730 740 750
EAAPAREGEG LAVSQAAHRT LKAVEADYDK LAFNKAVARI YELVNTLAAP
760 770 780 790 800
LAQIAAGKAD QALTAAVKDA AGILISLIAP MMPHLAEECW RAIGGKGLIA
810 820 830 840 850
ERPWPKFDAT LVVENEITLP VQINGKKRAD LTIARDADQS AIESAVLALD
860 870
VVKTALNGSN PKKIIVVPQR IVNVVV
Length:876
Mass (Da):98,092
Last modified:August 21, 2007 - v1
Checksum:i4AF876E12CEFBBBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000738 Genomic DNA Translation: ABR62022.1
RefSeqiWP_012067403.1, NC_009636.1
YP_001328857.1, NC_009636.1

Genome annotation databases

EnsemblBacteriaiABR62022; ABR62022; Smed_3198
GeneIDi5324077
KEGGismd:Smed_3198
PATRICifig|366394.8.peg.6436

Similar proteinsi

Entry informationi

Entry nameiSYL_SINMW
AccessioniPrimary (citable) accession number: A6UEE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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