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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotationSAAS annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:Smed_3018Imported
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)Imported
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_3018

Structurei

3D structure databases

ProteinModelPortaliA6UDW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 168Nudix hydrolaseInterPro annotationAdd BLAST154

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi56 – 77Nudix boxUniRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105EJF Bacteria
COG0494 LUCA
HOGENOMiHOG000066722
KOiK08311
OMAiRPCVGIM
OrthoDBiPOG091H0392

Family and domain databases

CDDicd03671 Ap4A_hydrolase_plant_like, 1 hit
HAMAPiMF_00298 Nudix_RppH, 1 hit
InterProiView protein in InterPro
IPR020476 Nudix_hydrolase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
IPR022927 RppH
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR00502 NUDIXFAMILY
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

A6UDW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEKGRVMK AEDLPYRPCV GAMVLNQQGL VWVGHRLAVG NSEYDGSPQL
60 70 80 90 100
WQMPQGGIDE GEDPLEAAYR ELYEETGIRS VSLIAEAPDW INYDLPSHLI
110 120 130 140 150
GIGLKGKYRG QRQRWYAFRF EGDESEIAIN PPPGGHEPEF DAWEWKPMHA
160 170
LPGLIVPFKR KAYEEIVATF SHLVR
Length:175
Mass (Da):19,835
Last modified:August 21, 2007 - v1
Checksum:i576C9F160B487BDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000738 Genomic DNA Translation: ABR61845.1
RefSeqiWP_012067226.1, NC_009636.1
YP_001328680.1, NC_009636.1

Genome annotation databases

EnsemblBacteriaiABR61845; ABR61845; Smed_3018
GeneIDi5323896
KEGGismd:Smed_3018
PATRICifig|366394.8.peg.6243

Entry informationi

Entry nameiA6UDW5_SINMW
AccessioniPrimary (citable) accession number: A6UDW5
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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