Reviewed, UniProtKB/Swiss-Prot A6UDD3 (HGD_SINMW)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	Smed_2833

Organism

Sinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]

Taxonomic identifier

366394 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O(2) = 4-maleylacetoacetate.
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Homogentisate 1,2-dioxygenase		PRO_1000019544
Sites
	Metal binding	349	1	Iron By similarity
	Metal binding	355	1	Iron By similarity
	Metal binding	385	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6UDD3-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 2C75617E743F9238	FASTA	453	50,785
	10 20 30 40 50 60 MLEKAERQRK AAPDQQRSAG YMPGFGNDFE TESLPGSLPQ GQNSPQKCNY GLYAEQLSGS 70 80 90 100 110 120 PFTAPRGTNE RSWLYRIRPS VRHTGRFTKI DYPHWKTAPH TPEHSLALGQ LRWSPLPAPS 130 140 150 160 170 180 QSLTFLQGIR TMTTAGDALT QVGMAAHAYA FNADMVDDYF FNADGELLIV PETGAFQVFT 190 200 210 220 230 240 ELGRIDVEPS EICLVPRGMM FKVTRLGDEK VWRGYICENY GAKFTLPDRG PIGANCLANP 250 260 270 280 290 300 RDFKTPVAAY EDKETPCRVQ VKWCGSFHTA EIAHSPLDVV AWHGNYAPYK YDLKTFSPVG 310 320 330 340 350 360 AILFDHPDPS IFTVLTAPSG EEGTANVDFV IFPPRWLVAE HTFRPPWYHR NIMSEFMGLI 370 380 390 400 410 420 HGRYDAKEEG FVPGGMSLHN MMLAHGPDFS GFEKASNGEL KPVKLDNTMA FMFETRFPQQ 430 440 450 LTTFAAELET LQDDYIDCWS GLERKFDGTP GIK

References

[1]

"Complete sequence of Sinorhizobium medicae WSM419 chromosome." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000738 Genomic DNA. Translation: ABR61663.1.
RefSeq	YP_001328498.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5323703.
GenomeReviews	Gene locus Smed_2833 in contig CP000738_GR.
KEGG	smd:Smed_2833.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_SINMW

Accession

Primary (citable) accession number: A6UDD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	November 4, 2008
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)