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A6UCL4 (AROB_SINMW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Smed_2564
OrganismSinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]
Taxonomic identifier366394 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3803803-dehydroquinate synthase HAMAP MF_00110
PRO_1000117499

Sequences

Sequence LengthMass (Da)Tools
A6UCL4 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 23615227D79765CF

FASTA38040,577
        10         20         30         40         50         60 
MKPMTSDVMP AAERKVRVDL AERSYDILIG PGLIAAAGGE IASRLKGRKM AVITDENVAP 

        70         80         90        100        110        120 
RYLEPLMASL AGSGMDPVSL ILPAGEKTKS FEHLIPVCEA VLGARIERND AVIALGGGVI 

       130        140        150        160        170        180 
GDLTGFAAGI VRRGSRFIQI PTSLLAQVDS SVGGKTGINS PHGKNLIGVF HQPDLVLADT 

       190        200        210        220        230        240 
AALDTLSPRE FRAGYAEVVK YGLIDKPDFF EWLEQNWQAV FAGGPARIEA IAVSCQAKAD 

       250        260        270        280        290        300 
VVAADERENG LRALLNLGHT FGHALEAATG YDSKRLVHGE GVAIGMVLAH EFSARMNIAS 

       310        320        330        340        350        360 
PDDARRVEMH LKTVGLPTRM ADIPGMLPPA DRLLEAIAQD KKVKGGKFTF ILTRGIGQSF 

       370        380 
IADDVPSSEV LSFLEERIPR

« Hide

References

[1]"Complete sequence of Sinorhizobium medicae WSM419 chromosome."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM419.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000738 Genomic DNA. Translation: ABR61394.1.
RefSeqYP_001328229.1. NC_009636.1.

3D structure databases

ProteinModelPortalA6UCL4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6UCL4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5323432.
GenomeReviewsGene locus Smed_2564 in contig CP000738_GR.
KEGGsmd:Smed_2564.
PATRIC23624253. VBISinMed134228_5756.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycSMED366394:SMED_2564-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_SINMW
AccessionPrimary (citable) accession number: A6UCL4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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