A6UC41 (URED_SINMW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease accessory protein UreD

Gene names

Name:	ureD
Ordered Locus Names:	Smed_2389

Organism

Sinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]

Taxonomic identifier

366394 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter By similarity. HAMAP MF_01384
Subunit structure	UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01384.
Sequence similarities	Belongs to the UreD family.

Ontologies

Keywords
Biological process	Nickel insertion
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Urease accessory protein UreD HAMAP MF_01384		PRO_0000340518

Sequences

	Sequence		Length	Mass (Da)
	A6UC41 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 6A4B60CACEED40FE	FASTA	277	29,400
	10 20 30 40 50 60 MEAAAAIAPQ RAWGKGRLVA KTGGARTRIA GLYQEGCAKI RLPRTFDASM EAVLINSSGG 70 80 90 100 110 120 VTGGDRLAWE FEAGEGTNLT LTTQACEKVY KASVDTAVVA TRISVAARGH VDWLPQESIL 130 140 150 160 170 180 FDRSALSRSL EVDLAPDASF LALEAVLIGR KAMGETVRSG LFRDHWRIRS GGALVHAENL 190 200 210 220 230 240 ALAGDIAALG SRRAVLDGAV AFATLVYVAP DCEALLPRLR TSLAEHALSG VSHFAVNGRD 250 260 270 KIVARVVAAD GFALRKILIP LISHLRKGAS VPRVWTL

References

[1]

"Complete sequence of Sinorhizobium medicae WSM419 chromosome." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WSM419.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000738 Genomic DNA. Translation: ABR61221.1.
RefSeq	YP_001328056.1. NC_009636.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6UC41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5323250.
GenomeReviews	Gene locus Smed_2389 in contig CP000738_GR.
KEGG	smd:Smed_2389.
PATRIC	23623871. VBISinMed134228_5572.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0829.
HOGENOM	HBG711156.
OMA	QETILFD.
ProtClustDB	CLSK2484748.
Enzyme and pathway databases
BioCyc	SMED366394:SMED_2389-MONOMER.
Family and domain databases
HAMAP	MF_01384. UreD. [Tree]
InterPro	IPR002669. UreD. [Graphical view]
KO	K03190.
Pfam	PF01774. UreD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

URED_SINMW

Accession

Primary (citable) accession number: A6UC41

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program