Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6UBV0 (FTHS_SINMW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Smed_2298
OrganismSinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]
Taxonomic identifier366394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 567567Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000318569

Regions

Nucleotide binding76 – 838ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6UBV0 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 112175D55AA5B11A

FASTA56761,461
        10         20         30         40         50         60 
MRKQLGEAVG EVKTDIEIAR AARKQPIMEV GARLGIPPEH LLPYGHDKAK VSAEFIAAQR 

        70         80         90        100        110        120 
EKKNGRLILV TAINPTPAGE GKTTTTVGLV DGLNRIGKKA IVCIREASLG PCFGIKGGAA 

       130        140        150        160        170        180 
GGGYAQVVPM EDINLHFTGD FHAITSAHNL LSALIDNHIY WGNEQAIDIR RIAWRRVMDM 

       190        200        210        220        230        240 
NDRALRHIVG SLGGVANGYP RETGFDITVA SEVMAILCLA MDIRDLERRL GNIIIGYRRD 

       250        260        270        280        290        300 
KSPVYARDIK ADGAMAVLLK DAMQPNLVQT LENNPAFVHG GPFANIAHGC NSVVATTTAL 

       310        320        330        340        350        360 
KLADYVVTEA GFGADLGAEK FFDIKCRKAG LMPDAAVIVA TVRAIKMNGG VKKEDLAKEN 

       370        380        390        400        410        420 
VEALRKGCPN LGRHIQNVKK FGVPVLVAIN HFTSDTEAEI QAIKDYVRTL GSEAVLCKHW 

       430        440        450        460        470        480 
AEGSAGIEEL ADKVADLADA GHSQFSPLYP DEMPLFQKIE AIAKDIYHAS EVIADKLVRD 

       490        500        510        520        530        540 
QLRIWEDQGY GHLPICMAKT QYSFSTDPNL RGAPTGHTVP IREVRLAAGA GFIVVITGEI 

       550        560 
MTMPGLPKVP SSERIRLDEE GYIEGLF 

« Hide

References

[1]"Complete sequence of Sinorhizobium medicae WSM419 chromosome."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM419.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000738 Genomic DNA. Translation: ABR61130.1.

3D structure databases

ProteinModelPortalA6UBV0.
SMRA6UBV0. Positions 15-565.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING366394.Smed_2298.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR61130; ABR61130; Smed_2298.
PATRIC23623677. VBISinMed134228_5475.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
OMANTIVQRI.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_SINMW
AccessionPrimary (citable) accession number: A6UBV0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways