Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A6UBV0

- FTHS_SINMW

UniProt

A6UBV0 - FTHS_SINMW

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi76 – 838ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Smed_2298
    OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
    Taxonomic identifieri366394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001108: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Formate--tetrahydrofolate ligasePRO_0000318569Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi366394.Smed_2298.

    Structurei

    3D structure databases

    ProteinModelPortaliA6UBV0.
    SMRiA6UBV0. Positions 15-565.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    OMAiNTIVQRI.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6UBV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKQLGEAVG EVKTDIEIAR AARKQPIMEV GARLGIPPEH LLPYGHDKAK    50
    VSAEFIAAQR EKKNGRLILV TAINPTPAGE GKTTTTVGLV DGLNRIGKKA 100
    IVCIREASLG PCFGIKGGAA GGGYAQVVPM EDINLHFTGD FHAITSAHNL 150
    LSALIDNHIY WGNEQAIDIR RIAWRRVMDM NDRALRHIVG SLGGVANGYP 200
    RETGFDITVA SEVMAILCLA MDIRDLERRL GNIIIGYRRD KSPVYARDIK 250
    ADGAMAVLLK DAMQPNLVQT LENNPAFVHG GPFANIAHGC NSVVATTTAL 300
    KLADYVVTEA GFGADLGAEK FFDIKCRKAG LMPDAAVIVA TVRAIKMNGG 350
    VKKEDLAKEN VEALRKGCPN LGRHIQNVKK FGVPVLVAIN HFTSDTEAEI 400
    QAIKDYVRTL GSEAVLCKHW AEGSAGIEEL ADKVADLADA GHSQFSPLYP 450
    DEMPLFQKIE AIAKDIYHAS EVIADKLVRD QLRIWEDQGY GHLPICMAKT 500
    QYSFSTDPNL RGAPTGHTVP IREVRLAAGA GFIVVITGEI MTMPGLPKVP 550
    SSERIRLDEE GYIEGLF 567
    Length:567
    Mass (Da):61,461
    Last modified:August 21, 2007 - v1
    Checksum:i112175D55AA5B11A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR61130.1.

    Genome annotation databases

    EnsemblBacteriaiABR61130; ABR61130; Smed_2298.
    PATRICi23623677. VBISinMed134228_5475.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR61130.1 .

    3D structure databases

    ProteinModelPortali A6UBV0.
    SMRi A6UBV0. Positions 15-565.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 366394.Smed_2298.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR61130 ; ABR61130 ; Smed_2298 .
    PATRICi 23623677. VBISinMed134228_5475.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    OMAi NTIVQRI.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WSM419.

    Entry informationi

    Entry nameiFTHS_SINMW
    AccessioniPrimary (citable) accession number: A6UBV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3