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A6UBV0

- FTHS_SINMW

UniProt

A6UBV0 - FTHS_SINMW

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Smed_2298
Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 838ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Smed_2298
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001108: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000318569Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_2298.

Structurei

3D structure databases

ProteinModelPortaliA6UBV0.
SMRiA6UBV0. Positions 15-565.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
OMAiNTIVQRI.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6UBV0-1 [UniParc]FASTAAdd to Basket

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MRKQLGEAVG EVKTDIEIAR AARKQPIMEV GARLGIPPEH LLPYGHDKAK    50
VSAEFIAAQR EKKNGRLILV TAINPTPAGE GKTTTTVGLV DGLNRIGKKA 100
IVCIREASLG PCFGIKGGAA GGGYAQVVPM EDINLHFTGD FHAITSAHNL 150
LSALIDNHIY WGNEQAIDIR RIAWRRVMDM NDRALRHIVG SLGGVANGYP 200
RETGFDITVA SEVMAILCLA MDIRDLERRL GNIIIGYRRD KSPVYARDIK 250
ADGAMAVLLK DAMQPNLVQT LENNPAFVHG GPFANIAHGC NSVVATTTAL 300
KLADYVVTEA GFGADLGAEK FFDIKCRKAG LMPDAAVIVA TVRAIKMNGG 350
VKKEDLAKEN VEALRKGCPN LGRHIQNVKK FGVPVLVAIN HFTSDTEAEI 400
QAIKDYVRTL GSEAVLCKHW AEGSAGIEEL ADKVADLADA GHSQFSPLYP 450
DEMPLFQKIE AIAKDIYHAS EVIADKLVRD QLRIWEDQGY GHLPICMAKT 500
QYSFSTDPNL RGAPTGHTVP IREVRLAAGA GFIVVITGEI MTMPGLPKVP 550
SSERIRLDEE GYIEGLF 567
Length:567
Mass (Da):61,461
Last modified:August 21, 2007 - v1
Checksum:i112175D55AA5B11A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR61130.1.

Genome annotation databases

EnsemblBacteriaiABR61130; ABR61130; Smed_2298.
PATRICi23623677. VBISinMed134228_5475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR61130.1 .

3D structure databases

ProteinModelPortali A6UBV0.
SMRi A6UBV0. Positions 15-565.
ModBasei Search...

Protein-protein interaction databases

STRINGi 366394.Smed_2298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR61130 ; ABR61130 ; Smed_2298 .
PATRICi 23623677. VBISinMed134228_5475.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
OMAi NTIVQRI.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM419.

Entry informationi

Entry nameiFTHS_SINMW
AccessioniPrimary (citable) accession number: A6UBV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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