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A6UB89 (A6UB89_SINMW) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136

EC=6.3.2.10 RuleBase RU004136
Gene names
Ordered Locus Names:Smed_2086 EMBL ABR60919.1
OrganismSinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP] EMBL ABR60919.1
Taxonomic identifier366394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
A6UB89 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 516C40CEA7B6A4BB

FASTA47749,808
        10         20         30         40         50         60 
MNWLWTSSDL LGAMNGRPVG NLPEGITGIS IDSRTIGNGE AFFAIRGDRV DGHDYAGIAL 

        70         80         90        100        110        120 
ANGAALLVVS EAKLPALGRL IAPMIVVDDV LEAMIRLGCA ARDRSAAKII AVTGSVGKTT 

       130        140        150        160        170        180 
TKEMLRHMLS PLGRVHASVA SFNNHWGVPL TLARMPETTD YGVFEIGMNH AGEIRPLTRM 

       190        200        210        220        230        240 
VRPHVAVVTS IAAAHLGNFA SLDDIAAAKA EIFEGVVNGG HAVINRDSAQ YELLEKAAAT 

       250        260        270        280        290        300 
AGVSHVHFFG ANPKSEFRLA EFAGGAEGSV LWAGVGGRTL EIAIGAPGRH IAENALAAIA 

       310        320        330        340        350        360 
AATLAGADTD RVAASLATMQ PEKGRGLRHR LRMGAGYMTL IDESYNANPA SMRAAITLLR 

       370        380        390        400        410        420 
DAEPSPGGRR IAILGDMLEM GEHSAAVHAA LARPIVDAGI ADVWLTGTEM AHLRDALPSE 

       430        440        450        460        470 
VSVVHRDLVS DLTAYALGAV AAGDVVMVKS SKSTGCAKIV QALLDAHPHD EAGKREA 

« Hide

References

[1]"Complete sequence of Sinorhizobium medicae WSM419 chromosome."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM419.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000738 Genomic DNA. Translation: ABR60919.1.
RefSeqYP_001327754.1. NC_009636.1.

3D structure databases

ProteinModelPortalA6UB89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING366394.Smed_2086.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR60919; ABR60919; Smed_2086.
GeneID5322945.
KEGGsmd:Smed_2086.
PATRIC23623213. VBISinMed134228_5244.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0770.
HOGENOMHOG000268120.
KOK01929.
OMAANHLGEI.
OrthoDBEOG6PKFCR.
ProtClustDBCLSK863318.

Enzyme and pathway databases

BioCycSMED366394:GJAL-2118-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6UB89_SINMW
AccessionPrimary (citable) accession number: A6UB89
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)