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A6UB89

- A6UB89_SINMW

UniProt

A6UB89 - A6UB89_SINMW

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Protein
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Gene
Smed_2086
Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Source: UniProtKB-EC
  3. UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMED366394:GJAL-2118-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
Gene namesi
Ordered Locus Names:Smed_2086Imported
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)Imported
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001108: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_2086.

Structurei

3D structure databases

ProteinModelPortaliA6UB89.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0770.
HOGENOMiHOG000268120.
KOiK01929.
OMAiGGYAKSK.
OrthoDBiEOG6PKFCR.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERiPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR01143. murF. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UB89-1 [UniParc]FASTAAdd to Basket

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MNWLWTSSDL LGAMNGRPVG NLPEGITGIS IDSRTIGNGE AFFAIRGDRV    50
DGHDYAGIAL ANGAALLVVS EAKLPALGRL IAPMIVVDDV LEAMIRLGCA 100
ARDRSAAKII AVTGSVGKTT TKEMLRHMLS PLGRVHASVA SFNNHWGVPL 150
TLARMPETTD YGVFEIGMNH AGEIRPLTRM VRPHVAVVTS IAAAHLGNFA 200
SLDDIAAAKA EIFEGVVNGG HAVINRDSAQ YELLEKAAAT AGVSHVHFFG 250
ANPKSEFRLA EFAGGAEGSV LWAGVGGRTL EIAIGAPGRH IAENALAAIA 300
AATLAGADTD RVAASLATMQ PEKGRGLRHR LRMGAGYMTL IDESYNANPA 350
SMRAAITLLR DAEPSPGGRR IAILGDMLEM GEHSAAVHAA LARPIVDAGI 400
ADVWLTGTEM AHLRDALPSE VSVVHRDLVS DLTAYALGAV AAGDVVMVKS 450
SKSTGCAKIV QALLDAHPHD EAGKREA 477
Length:477
Mass (Da):49,808
Last modified:August 21, 2007 - v1
Checksum:i516C40CEA7B6A4BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR60919.1.
RefSeqiYP_001327754.1. NC_009636.1.

Genome annotation databases

EnsemblBacteriaiABR60919; ABR60919; Smed_2086.
GeneIDi5322945.
KEGGismd:Smed_2086.
PATRICi23623213. VBISinMed134228_5244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR60919.1 .
RefSeqi YP_001327754.1. NC_009636.1.

3D structure databases

ProteinModelPortali A6UB89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366394.Smed_2086.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR60919 ; ABR60919 ; Smed_2086 .
GeneIDi 5322945.
KEGGi smd:Smed_2086.
PATRICi 23623213. VBISinMed134228_5244.

Phylogenomic databases

eggNOGi COG0770.
HOGENOMi HOG000268120.
KOi K01929.
OMAi GGYAKSK.
OrthoDBi EOG6PKFCR.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SMED366394:GJAL-2118-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view ]
PANTHERi PTHR23135:SF3. PTHR23135:SF3. 1 hit.
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsi TIGR01143. murF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM419.

Entry informationi

Entry nameiA6UB89_SINMW
AccessioniPrimary (citable) accession number: A6UB89
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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