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A6UB89

- A6UB89_SINMW

UniProt

A6UB89 - A6UB89_SINMW

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Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

Smed_2086

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Source: InterPro
  3. UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMED366394:GJAL-2118-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
Gene namesi
Ordered Locus Names:Smed_2086Imported
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)Imported
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001108: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_2086.

Structurei

3D structure databases

ProteinModelPortaliA6UB89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0770.
HOGENOMiHOG000268120.
KOiK01929.
OMAiGGYAKSK.
OrthoDBiEOG6PKFCR.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERiPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR01143. murF. 1 hit.

Sequencei

Sequence statusi: Complete.

A6UB89-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNWLWTSSDL LGAMNGRPVG NLPEGITGIS IDSRTIGNGE AFFAIRGDRV
60 70 80 90 100
DGHDYAGIAL ANGAALLVVS EAKLPALGRL IAPMIVVDDV LEAMIRLGCA
110 120 130 140 150
ARDRSAAKII AVTGSVGKTT TKEMLRHMLS PLGRVHASVA SFNNHWGVPL
160 170 180 190 200
TLARMPETTD YGVFEIGMNH AGEIRPLTRM VRPHVAVVTS IAAAHLGNFA
210 220 230 240 250
SLDDIAAAKA EIFEGVVNGG HAVINRDSAQ YELLEKAAAT AGVSHVHFFG
260 270 280 290 300
ANPKSEFRLA EFAGGAEGSV LWAGVGGRTL EIAIGAPGRH IAENALAAIA
310 320 330 340 350
AATLAGADTD RVAASLATMQ PEKGRGLRHR LRMGAGYMTL IDESYNANPA
360 370 380 390 400
SMRAAITLLR DAEPSPGGRR IAILGDMLEM GEHSAAVHAA LARPIVDAGI
410 420 430 440 450
ADVWLTGTEM AHLRDALPSE VSVVHRDLVS DLTAYALGAV AAGDVVMVKS
460 470
SKSTGCAKIV QALLDAHPHD EAGKREA
Length:477
Mass (Da):49,808
Last modified:August 21, 2007 - v1
Checksum:i516C40CEA7B6A4BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000738 Genomic DNA. Translation: ABR60919.1.
RefSeqiYP_001327754.1. NC_009636.1.

Genome annotation databases

EnsemblBacteriaiABR60919; ABR60919; Smed_2086.
GeneIDi5322945.
KEGGismd:Smed_2086.
PATRICi23623213. VBISinMed134228_5244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000738 Genomic DNA. Translation: ABR60919.1 .
RefSeqi YP_001327754.1. NC_009636.1.

3D structure databases

ProteinModelPortali A6UB89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366394.Smed_2086.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR60919 ; ABR60919 ; Smed_2086 .
GeneIDi 5322945.
KEGGi smd:Smed_2086.
PATRICi 23623213. VBISinMed134228_5244.

Phylogenomic databases

eggNOGi COG0770.
HOGENOMi HOG000268120.
KOi K01929.
OMAi GGYAKSK.
OrthoDBi EOG6PKFCR.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SMED366394:GJAL-2118-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view ]
PANTHERi PTHR23135:SF3. PTHR23135:SF3. 1 hit.
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsi TIGR01143. murF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM419Imported.

Entry informationi

Entry nameiA6UB89_SINMW
AccessioniPrimary (citable) accession number: A6UB89
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3