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A6UB89

- A6UB89_SINMW

UniProt

A6UB89 - A6UB89_SINMW

Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

Smed_2086

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.UniRule annotation
    Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

    Catalytic activityi

    ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Source: InterPro
    3. UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMED366394:GJAL-2118-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
    Gene namesi
    Ordered Locus Names:Smed_2086Imported
    OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)Imported
    Taxonomic identifieri366394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001108: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation
    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Interactioni

    Protein-protein interaction databases

    STRINGi366394.Smed_2086.

    Structurei

    3D structure databases

    ProteinModelPortaliA6UB89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0770.
    HOGENOMiHOG000268120.
    KOiK01929.
    OMAiGGYAKSK.
    OrthoDBiEOG6PKFCR.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProiIPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005863. UDP-N-AcMur-pentapeptide_synth.
    [Graphical view]
    PANTHERiPTHR23135:SF3. PTHR23135:SF3. 1 hit.
    PfamiPF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsiTIGR01143. murF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6UB89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNWLWTSSDL LGAMNGRPVG NLPEGITGIS IDSRTIGNGE AFFAIRGDRV    50
    DGHDYAGIAL ANGAALLVVS EAKLPALGRL IAPMIVVDDV LEAMIRLGCA 100
    ARDRSAAKII AVTGSVGKTT TKEMLRHMLS PLGRVHASVA SFNNHWGVPL 150
    TLARMPETTD YGVFEIGMNH AGEIRPLTRM VRPHVAVVTS IAAAHLGNFA 200
    SLDDIAAAKA EIFEGVVNGG HAVINRDSAQ YELLEKAAAT AGVSHVHFFG 250
    ANPKSEFRLA EFAGGAEGSV LWAGVGGRTL EIAIGAPGRH IAENALAAIA 300
    AATLAGADTD RVAASLATMQ PEKGRGLRHR LRMGAGYMTL IDESYNANPA 350
    SMRAAITLLR DAEPSPGGRR IAILGDMLEM GEHSAAVHAA LARPIVDAGI 400
    ADVWLTGTEM AHLRDALPSE VSVVHRDLVS DLTAYALGAV AAGDVVMVKS 450
    SKSTGCAKIV QALLDAHPHD EAGKREA 477
    Length:477
    Mass (Da):49,808
    Last modified:August 21, 2007 - v1
    Checksum:i516C40CEA7B6A4BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR60919.1.
    RefSeqiYP_001327754.1. NC_009636.1.

    Genome annotation databases

    EnsemblBacteriaiABR60919; ABR60919; Smed_2086.
    GeneIDi5322945.
    KEGGismd:Smed_2086.
    PATRICi23623213. VBISinMed134228_5244.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR60919.1 .
    RefSeqi YP_001327754.1. NC_009636.1.

    3D structure databases

    ProteinModelPortali A6UB89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 366394.Smed_2086.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR60919 ; ABR60919 ; Smed_2086 .
    GeneIDi 5322945.
    KEGGi smd:Smed_2086.
    PATRICi 23623213. VBISinMed134228_5244.

    Phylogenomic databases

    eggNOGi COG0770.
    HOGENOMi HOG000268120.
    KOi K01929.
    OMAi GGYAKSK.
    OrthoDBi EOG6PKFCR.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci SMED366394:GJAL-2118-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProi IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005863. UDP-N-AcMur-pentapeptide_synth.
    [Graphical view ]
    PANTHERi PTHR23135:SF3. PTHR23135:SF3. 1 hit.
    Pfami PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsi TIGR01143. murF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WSM419Imported.

    Entry informationi

    Entry nameiA6UB89_SINMW
    AccessioniPrimary (citable) accession number: A6UB89
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3