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A6U8Q3 (GCSP_SINMW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Smed_1182
OrganismSinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]
Taxonomic identifier366394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045620

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6U8Q3 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 9A09A8613FE27986

FASTA954104,061
        10         20         30         40         50         60 
MSMPKDFTFT DYKPYDFANR RHIGPSPAEM DEMLKVVGYP SLDALIDDTV PPSIRQQTPL 

        70         80         90        100        110        120 
AWGAPMTERE ALDKLRETAN RNRKVVSLIG QGYYGTITPP VIQRNILENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNFQTMVCD LTGLDVANAS LLDEATAAAE AMAIAERVAK SKAKAFFVDE 

       190        200        210        220        230        240 
NCHPQTIALL KTRAEPLGWQ IVVGNPFEDL DAAIVFGAIF QYPGTYGHVR DFSGLIARLH 

       250        260        270        280        290        300 
ELGAIAAVAA DPLALALLKS PGEMGADIAV GSTQRFGVPV GYGGPHAAYM AVRDAYKRSM 

       310        320        330        340        350        360 
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM YAVFHGPEGI 

       370        380        390        400        410        420 
KAIAQSVHQK TVRLALGLEK LGYTVEPDVF FDTITVEVGK LQGIILKAAV AEDVNLRKIG 

       430        440        450        460        470        480 
TTKIGISLDE RSRPITLEAV WRAFGGDFSV DQFEPDYRLP KELLRTSDYL THPIFHMNRA 

       490        500        510        520        530        540 
ESEMTRYMRR LADRDLALDR AMIPLGSCTM KLNATAEMLP ITWPEFSEIH PFVPADQAMG 

       550        560        570        580        590        600 
YHHLIEDLSQ KLCAITGYDA ISMQPNSGAQ GEYAGLLAIR AYHIANGNEH RDVCLIPTSA 

       610        620        630        640        650        660 
HGTNPASAQM AGMKVVVVKV SDAGEIAMDD FRAKAEQYAE TLSCCMITYP STHGVFEENV 

       670        680        690        700        710        720 
REVCEIVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL NLHKTFCIPH GGGGPGMGPI 

       730        740        750        760        770        780 
GVKAHLAPFL PGHPESGEHK GAVSAAPFGS ASILPISWSY CLMMGGEGLT QATKVAILNA 

       790        800        810        820        830        840 
NYVAARLKGA FDVLYKSAKG RVAHECIIDT RPLAESAGVT VDDVAKRLID CGFHAPTMSW 

       850        860        870        880        890        900 
PVAGTLMIEP TESETKAELD RFCDALLAIR EEARAIAEGR MDKINNPLKN APHTVEDLVG 

       910        920        930        940        950 
DWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLV CTCPPIESYA EAAE 

« Hide

References

[1]"Complete sequence of Sinorhizobium medicae WSM419 chromosome."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM419.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000738 Genomic DNA. Translation: ABR60033.1.
RefSeqYP_001326868.1. NC_009636.1.

3D structure databases

ProteinModelPortalA6U8Q3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING366394.Smed_1182.

Proteomic databases

PRIDEA6U8Q3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR60033; ABR60033; Smed_1182.
GeneID5322029.
KEGGsmd:Smed_1182.
PATRIC23621318. VBISinMed134228_4310.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycSMED366394:GJAL-1203-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SINMW
AccessionPrimary (citable) accession number: A6U8Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families