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A6U8Q3

- GCSP_SINMW

UniProt

A6U8Q3 - GCSP_SINMW

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSMED366394:GJAL-1203-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Smed_1182
    OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
    Taxonomic identifieri366394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001108: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000045620Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiA6U8Q3.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi366394.Smed_1182.

    Structurei

    3D structure databases

    ProteinModelPortaliA6U8Q3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6U8Q3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMPKDFTFT DYKPYDFANR RHIGPSPAEM DEMLKVVGYP SLDALIDDTV    50
    PPSIRQQTPL AWGAPMTERE ALDKLRETAN RNRKVVSLIG QGYYGTITPP 100
    VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNFQTMVCD LTGLDVANAS 150
    LLDEATAAAE AMAIAERVAK SKAKAFFVDE NCHPQTIALL KTRAEPLGWQ 200
    IVVGNPFEDL DAAIVFGAIF QYPGTYGHVR DFSGLIARLH ELGAIAAVAA 250
    DPLALALLKS PGEMGADIAV GSTQRFGVPV GYGGPHAAYM AVRDAYKRSM 300
    PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
    YAVFHGPEGI KAIAQSVHQK TVRLALGLEK LGYTVEPDVF FDTITVEVGK 400
    LQGIILKAAV AEDVNLRKIG TTKIGISLDE RSRPITLEAV WRAFGGDFSV 450
    DQFEPDYRLP KELLRTSDYL THPIFHMNRA ESEMTRYMRR LADRDLALDR 500
    AMIPLGSCTM KLNATAEMLP ITWPEFSEIH PFVPADQAMG YHHLIEDLSQ 550
    KLCAITGYDA ISMQPNSGAQ GEYAGLLAIR AYHIANGNEH RDVCLIPTSA 600
    HGTNPASAQM AGMKVVVVKV SDAGEIAMDD FRAKAEQYAE TLSCCMITYP 650
    STHGVFEENV REVCEIVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL 700
    NLHKTFCIPH GGGGPGMGPI GVKAHLAPFL PGHPESGEHK GAVSAAPFGS 750
    ASILPISWSY CLMMGGEGLT QATKVAILNA NYVAARLKGA FDVLYKSAKG 800
    RVAHECIIDT RPLAESAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
    TESETKAELD RFCDALLAIR EEARAIAEGR MDKINNPLKN APHTVEDLVG 900
    DWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLV CTCPPIESYA 950
    EAAE 954
    Length:954
    Mass (Da):104,061
    Last modified:August 21, 2007 - v1
    Checksum:i9A09A8613FE27986
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR60033.1.
    RefSeqiYP_001326868.1. NC_009636.1.

    Genome annotation databases

    EnsemblBacteriaiABR60033; ABR60033; Smed_1182.
    GeneIDi5322029.
    KEGGismd:Smed_1182.
    PATRICi23621318. VBISinMed134228_4310.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR60033.1 .
    RefSeqi YP_001326868.1. NC_009636.1.

    3D structure databases

    ProteinModelPortali A6U8Q3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 366394.Smed_1182.

    Proteomic databases

    PRIDEi A6U8Q3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR60033 ; ABR60033 ; Smed_1182 .
    GeneIDi 5322029.
    KEGGi smd:Smed_1182.
    PATRICi 23621318. VBISinMed134228_4310.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SMED366394:GJAL-1203-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WSM419.

    Entry informationi

    Entry nameiGCSP_SINMW
    AccessioniPrimary (citable) accession number: A6U8Q3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3