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A6U8Q3

- GCSP_SINMW

UniProt

A6U8Q3 - GCSP_SINMW

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Smed_1182
Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSMED366394:GJAL-1203-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Smed_1182
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001108: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA6U8Q3.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi366394.Smed_1182.

Structurei

3D structure databases

ProteinModelPortaliA6U8Q3.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A6U8Q3-1 [UniParc]FASTAAdd to Basket

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MSMPKDFTFT DYKPYDFANR RHIGPSPAEM DEMLKVVGYP SLDALIDDTV    50
PPSIRQQTPL AWGAPMTERE ALDKLRETAN RNRKVVSLIG QGYYGTITPP 100
VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNFQTMVCD LTGLDVANAS 150
LLDEATAAAE AMAIAERVAK SKAKAFFVDE NCHPQTIALL KTRAEPLGWQ 200
IVVGNPFEDL DAAIVFGAIF QYPGTYGHVR DFSGLIARLH ELGAIAAVAA 250
DPLALALLKS PGEMGADIAV GSTQRFGVPV GYGGPHAAYM AVRDAYKRSM 300
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
YAVFHGPEGI KAIAQSVHQK TVRLALGLEK LGYTVEPDVF FDTITVEVGK 400
LQGIILKAAV AEDVNLRKIG TTKIGISLDE RSRPITLEAV WRAFGGDFSV 450
DQFEPDYRLP KELLRTSDYL THPIFHMNRA ESEMTRYMRR LADRDLALDR 500
AMIPLGSCTM KLNATAEMLP ITWPEFSEIH PFVPADQAMG YHHLIEDLSQ 550
KLCAITGYDA ISMQPNSGAQ GEYAGLLAIR AYHIANGNEH RDVCLIPTSA 600
HGTNPASAQM AGMKVVVVKV SDAGEIAMDD FRAKAEQYAE TLSCCMITYP 650
STHGVFEENV REVCEIVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKAHLAPFL PGHPESGEHK GAVSAAPFGS 750
ASILPISWSY CLMMGGEGLT QATKVAILNA NYVAARLKGA FDVLYKSAKG 800
RVAHECIIDT RPLAESAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
TESETKAELD RFCDALLAIR EEARAIAEGR MDKINNPLKN APHTVEDLVG 900
DWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLV CTCPPIESYA 950
EAAE 954
Length:954
Mass (Da):104,061
Last modified:August 21, 2007 - v1
Checksum:i9A09A8613FE27986
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR60033.1.
RefSeqiYP_001326868.1. NC_009636.1.

Genome annotation databases

EnsemblBacteriaiABR60033; ABR60033; Smed_1182.
GeneIDi5322029.
KEGGismd:Smed_1182.
PATRICi23621318. VBISinMed134228_4310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR60033.1 .
RefSeqi YP_001326868.1. NC_009636.1.

3D structure databases

ProteinModelPortali A6U8Q3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366394.Smed_1182.

Proteomic databases

PRIDEi A6U8Q3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR60033 ; ABR60033 ; Smed_1182 .
GeneIDi 5322029.
KEGGi smd:Smed_1182.
PATRICi 23621318. VBISinMed134228_4310.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SMED366394:GJAL-1203-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM419.

Entry informationi

Entry nameiGCSP_SINMW
AccessioniPrimary (citable) accession number: A6U8Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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