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A6U8P9

- TRMFO_SINMW

UniProt

A6U8P9 - TRMFO_SINMW

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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FAD.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206FADUniRule annotation

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciSMED366394:GJAL-1198-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Synonyms:gid
Ordered Locus Names:Smed_1178
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001108: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_1000063928Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_1178.

Structurei

3D structure databases

ProteinModelPortaliA6U8P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiWEMRAAG.
OrthoDBiEOG6J74VT.

Family and domain databases

HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6U8P9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKLTSSYSP VHVIGGGLAG SEAAWQIAEA GVPVILHEMR GVRGTDAHKT
60 70 80 90 100
DSLAELVCSN SFRSDDATSN AVGVLHAEMR LAGSIIMRCA DLNQVPAGGA
110 120 130 140 150
LAVDREGFAE AVSAAIAAHP LITVLREEIR GLPPKEWDLA IIATGPLTAP
160 170 180 190 200
DLADAIRAET GADALAFFDA IAPIVHADTI DMDICWHQSR YDKVGPGGTG
210 220 230 240 250
KDYINCPLTQ EEYNAFIDAL IAGDKTGFKE WEGTPYFDGC LPIEVMAERG
260 270 280 290 300
RETLRHGPMK PMGLTNAHNP SVKPYAVVQL RQDNALGTLY NMVGFQTKLK
310 320 330 340 350
YGAQGEVFRM IPGLEKAEFA RLGGLHRNTY INSPTLLDQS LTLKSRAGLR
360 370 380 390 400
FAGQITGCEG YVESASIGLL AGRFAAAERK GASPAIPPVT TAFGALLNHI
410 420 430 440 450
TGGHIVSDDE PGKRSFQPMN VNFGLFPPLD PGALTRPEGA KRFRGKEKAS
460 470 480
AKKQAMASRA LSDCATWLDK NLLIGGAATR
Length:480
Mass (Da):51,129
Last modified:August 21, 2007 - v1
Checksum:iAA6A7587022C1B28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR60029.1.
RefSeqiYP_001326864.1. NC_009636.1.

Genome annotation databases

EnsemblBacteriaiABR60029; ABR60029; Smed_1178.
GeneIDi5322024.
KEGGismd:Smed_1178.
PATRICi23621306. VBISinMed134228_4305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR60029.1 .
RefSeqi YP_001326864.1. NC_009636.1.

3D structure databases

ProteinModelPortali A6U8P9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366394.Smed_1178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR60029 ; ABR60029 ; Smed_1178 .
GeneIDi 5322024.
KEGGi smd:Smed_1178.
PATRICi 23621306. VBISinMed134228_4305.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi WEMRAAG.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci SMED366394:GJAL-1198-MONOMER.

Family and domain databases

HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
PROSITEi PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM419.

Entry informationi

Entry nameiTRMFO_SINMW
AccessioniPrimary (citable) accession number: A6U8P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3