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A6U8P9

- TRMFO_SINMW

UniProt

A6U8P9 - TRMFO_SINMW

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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene
trmFO, gid, Smed_1178
Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206FAD By similarity

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciSMED366394:GJAL-1198-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (EC:2.1.1.74)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase
Folate-dependent tRNA(M-5-U54)-methyltransferase
Gene namesi
Name:trmFO
Synonyms:gid
Ordered Locus Names:Smed_1178
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001108: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotationPRO_1000063928Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_1178.

Structurei

3D structure databases

ProteinModelPortaliA6U8P9.

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiWEMRAAG.
OrthoDBiEOG6J74VT.

Family and domain databases

HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6U8P9-1 [UniParc]FASTAAdd to Basket

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MNKLTSSYSP VHVIGGGLAG SEAAWQIAEA GVPVILHEMR GVRGTDAHKT    50
DSLAELVCSN SFRSDDATSN AVGVLHAEMR LAGSIIMRCA DLNQVPAGGA 100
LAVDREGFAE AVSAAIAAHP LITVLREEIR GLPPKEWDLA IIATGPLTAP 150
DLADAIRAET GADALAFFDA IAPIVHADTI DMDICWHQSR YDKVGPGGTG 200
KDYINCPLTQ EEYNAFIDAL IAGDKTGFKE WEGTPYFDGC LPIEVMAERG 250
RETLRHGPMK PMGLTNAHNP SVKPYAVVQL RQDNALGTLY NMVGFQTKLK 300
YGAQGEVFRM IPGLEKAEFA RLGGLHRNTY INSPTLLDQS LTLKSRAGLR 350
FAGQITGCEG YVESASIGLL AGRFAAAERK GASPAIPPVT TAFGALLNHI 400
TGGHIVSDDE PGKRSFQPMN VNFGLFPPLD PGALTRPEGA KRFRGKEKAS 450
AKKQAMASRA LSDCATWLDK NLLIGGAATR 480
Length:480
Mass (Da):51,129
Last modified:August 21, 2007 - v1
Checksum:iAA6A7587022C1B28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR60029.1.
RefSeqiYP_001326864.1. NC_009636.1.

Genome annotation databases

EnsemblBacteriaiABR60029; ABR60029; Smed_1178.
GeneIDi5322024.
KEGGismd:Smed_1178.
PATRICi23621306. VBISinMed134228_4305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000738 Genomic DNA. Translation: ABR60029.1 .
RefSeqi YP_001326864.1. NC_009636.1.

3D structure databases

ProteinModelPortali A6U8P9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366394.Smed_1178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR60029 ; ABR60029 ; Smed_1178 .
GeneIDi 5322024.
KEGGi smd:Smed_1178.
PATRICi 23621306. VBISinMed134228_4305.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi WEMRAAG.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci SMED366394:GJAL-1198-MONOMER.

Family and domain databases

HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
PROSITEi PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM419.

Entry informationi

Entry nameiTRMFO_SINMW
AccessioniPrimary (citable) accession number: A6U8P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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