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A6U8L2

- LPXA_SINMW

UniProt

A6U8L2 - LPXA_SINMW

Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSMED366394:GJAL-1161-MONOMER.
    UniPathwayiUPA00359; UER00477.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
    Short name:
    UDP-N-acetylglucosamine acyltransferaseUniRule annotation
    Gene namesi
    Name:lpxAUniRule annotation
    Ordered Locus Names:Smed_1141
    OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
    Taxonomic identifieri366394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001108: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferasePRO_1000122734Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi366394.Smed_1141.

    Structurei

    3D structure databases

    ProteinModelPortaliA6U8L2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1043.
    HOGENOMiHOG000294326.
    KOiK00677.
    OMAiDHIKLND.
    OrthoDBiEOG6F81P1.

    Family and domain databases

    Gene3Di1.20.1180.10. 1 hit.
    HAMAPiMF_00387. LpxA.
    InterProiIPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6U8L2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIASSAKIHP SSAIEGGAVI GENVKIGPFC HIGPNVVLAD EVEILSHVTV    50
    IGRTTVGKGT KIFPGAVIGG DSQSMHHSAL NTTLVIGENC TIREGVTMNT 100
    GTVEHGGATI VGDNNLFLAY SHVAHDCRLG NNIILSNNVM LAGHVTVADR 150
    AILGGGSAVH QFTRIGRQAF IGGLSAVSYD VIPYGMLNGN PGLLSGLNVV 200
    GMTRAGFDRS TIHRVRRCYK QIFEGDGSIR ANAAAIRDEY LDCAPALEIL 250
    DFIAAESDRA LSSPNRGAKG 270
    Length:270
    Mass (Da):28,197
    Last modified:August 21, 2007 - v1
    Checksum:iE15C9A8A272DBEB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR59992.1.
    RefSeqiYP_001326827.1. NC_009636.1.

    Genome annotation databases

    EnsemblBacteriaiABR59992; ABR59992; Smed_1141.
    GeneIDi5321987.
    KEGGismd:Smed_1141.
    PATRICi23621228. VBISinMed134228_4266.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000738 Genomic DNA. Translation: ABR59992.1 .
    RefSeqi YP_001326827.1. NC_009636.1.

    3D structure databases

    ProteinModelPortali A6U8L2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 366394.Smed_1141.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR59992 ; ABR59992 ; Smed_1141 .
    GeneIDi 5321987.
    KEGGi smd:Smed_1141.
    PATRICi 23621228. VBISinMed134228_4266.

    Phylogenomic databases

    eggNOGi COG1043.
    HOGENOMi HOG000294326.
    KOi K00677.
    OMAi DHIKLND.
    OrthoDBi EOG6F81P1.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00477 .
    BioCyci SMED366394:GJAL-1161-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1180.10. 1 hit.
    HAMAPi MF_00387. LpxA.
    InterProi IPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Sinorhizobium medicae WSM419 chromosome."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WSM419.

    Entry informationi

    Entry nameiLPXA_SINMW
    AccessioniPrimary (citable) accession number: A6U8L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3