A6U8E0 (A6U8E0_SINMW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase 1 HAMAP MF_00147
Short name=TIM 1 HAMAP MF_00147
EC=5.3.1.1 HAMAP MF_00147

Alternative name(s):
Triose-phosphate isomerase 1 HAMAP MF_00147

Gene names

Name:	tpiA1 HAMAP MF_00147
Ordered Locus Names:	Smed_1067

Organism

Sinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]

Taxonomic identifier

366394 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147 RuleBase RU000517
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147 RuleBase RU003527 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147 RuleBase RU003527
Subunit structure	Homodimer By similarity. HAMAP MF_00147
Subcellular location	Cytoplasm By similarity HAMAP MF_00147.
Sequence similarities	Belongs to the triosephosphate isomerase family. RuleBase RU004162 HAMAP MF_00147

Ontologies

Keywords
Biological process	Gluconeogenesis HAMAP MF_00147 RuleBase RU003527 Glycolysis HAMAP MF_00147 RuleBase RU003527 Pentose shunt HAMAP MF_00147 RuleBase RU003527
Cellular component	Cytoplasm HAMAP MF_00147
Molecular function	Isomerase HAMAP MF_00147 RuleBase RU000517 EMBL ABR59920.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	99	1	Electrophile By similarity HAMAP MF_00147
	Active site	169	1	Proton acceptor By similarity HAMAP MF_00147
	Binding site	12	1	Substrate By similarity HAMAP MF_00147
	Binding site	14	1	Substrate By similarity HAMAP MF_00147

Sequences

	Sequence		Length	Mass (Da)
	A6U8E0 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: A4386EC31694F558	FASTA	256	26,883
	10 20 30 40 50 60 MTPDIRPLVA GNWKMNGTRA SLDQIKAIAE GVKGGLSARV DALICPPATL LYVATALCDD 70 80 90 100 110 120 SPLLIGAQDC HQKPSGAHTG EVSAEMIADC FGTHVIVGHS ERRSDHGEGD ALVCAKTEAA 130 140 150 160 170 180 HGAGLVAIVC IGETEGERKE GRTLDILKRQ LAGSLPDQAT AENTVIAYEP VWAIGTGLTP 190 200 210 220 230 240 TASDVEEAHA FMRRELVARF GAEGSKMRIL YGGSVKPSNA RELMGVTNVD GALIGGASLK 250 ADDFLAIYRA YEELTA

References

[1]

"Complete sequence of Sinorhizobium medicae WSM419 chromosome." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WSM419.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000738 Genomic DNA. Translation: ABR59920.1.
RefSeq	YP_001326755.1. NC_009636.1.
3D structure databases
ProteinModelPortal	A6U8E0.
ModBase	Search...
Protein-protein interaction databases
STRING	A6U8E0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5321913.
GenomeReviews	Gene locus Smed_1067 in contig CP000738_GR.
KEGG	smd:Smed_1067.
PATRIC	23621076. VBISinMed134228_4190.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0149.
HOGENOM	HBG708281.
OMA	IEKNGTM.
ProtClustDB	PRK00042.
Enzyme and pathway databases
BioCyc	SMED366394:SMED_1067-MONOMER.
Family and domain databases
HAMAP	MF_00147_B. TIM_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01803.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
TIGRFAMs	TIGR00419. Tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A6U8E0_SINMW

Accession

Primary (citable) accession number: A6U8E0

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)