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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ), Phosphoribosylformylglycinamidine synthase subunit PurS (purS), Phosphoribosylformylglycinamidine synthase subunit PurL (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Smed_0792
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001108 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000464731 – 356Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST356

Proteomic databases

PRIDEiA6U7L8

Interactioni

Protein-protein interaction databases

STRINGi366394.Smed_0792

Structurei

3D structure databases

ProteinModelPortaliA6U7L8
SMRiA6U7L8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229091
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG091H0128

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

A6U7L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSGKNGLT YSDAGVDIDA GNLMVEKIKP HVRSTRRPGA DGEIGGFGGL
60 70 80 90 100
FDLKAAGFSD PVLVAANDGV GTKLKIAIDA GKHDTVGIDL VAMCVNDLVV
110 120 130 140 150
QGAEPLFFLD YFATGKLDPD QGAAIVAGIA AGCREAGCAL IGGETAEMPG
160 170 180 190 200
MYSGGDYDLA GFAVGAAERG QLLPAGNIAE GDVILGLSSS GVHSNGYSLV
210 220 230 240 250
RKIVSLSGLA WDAPAPFGDG TVADLLMTPT RIYVKPLLKA IRETGAIKAL
260 270 280 290 300
AHITGGGFPE NIPRVLPKPL AAEIDLDAIK PPAVFSWLAK TGGVAANEML
310 320 330 340 350
RTFNCGVGMI AVVSAGEAEK VAAVLAREGE TVFTLGRMVS RSEDAPGTIY

KGNLAI
Length:356
Mass (Da):36,426
Last modified:August 21, 2007 - v1
Checksum:i54CC53A232858FFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000738 Genomic DNA Translation: ABR59648.1
RefSeqiWP_011974990.1, NC_009636.1
YP_001326483.1, NC_009636.1

Genome annotation databases

EnsemblBacteriaiABR59648; ABR59648; Smed_0792
GeneIDi5321629
KEGGismd:Smed_0792
PATRICifig|366394.8.peg.3905

Similar proteinsi

Entry informationi

Entry nameiPUR5_SINMW
AccessioniPrimary (citable) accession number: A6U7L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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