Reviewed, UniProtKB/Swiss-Prot A6U6Y9 (BETB_SINMW)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Smed_0563

Organism

Sinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]

Taxonomic identifier

366394 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_1000047058
Regions
	Nucleotide binding	228 – 233	6	NAD By similarity
Sites
	Active site	250	1	By similarity
	Active site	284	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6U6Y9-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 266AE71AACA3830A	FASTA	487	51,971
	10 20 30 40 50 60 MRAQPKASHF IDGEYVEDAA GTVIESIYPA TGEVIARLYA ATPAIVEKAI AAAKRAQPEW 70 80 90 100 110 120 AAMSPTARGR ILKRAAEIMR ERNRELSELE TLDTGKPIQE TIVADPTSGA DSFEFFGGIA 130 140 150 160 170 180 PAALNGDYIP LGGDFAYTKR VPLGVCVGIG AWNYPQQIAC WKGAPALVAG NSMVFKPSEN 190 200 210 220 230 240 TPLGALKIAE ILIEAGLPKG LYNVVQGDRS TGPLLVNHPD VAKVSLTGSV PTGRKVYEAA 250 260 270 280 290 300 AAGLRHVTME LGGKSPLIVF DDADLESAIG GAMLGNFYST GQVCSNGTRV FVQKKIKQSF 310 320 330 340 350 360 LARLKERTDA IVIGDPMDEA TQLGPMVSTA QRDKVFSYIE KGKSEGARLV TGGGIPNNVS 370 380 390 400 410 420 AEGTYIQPTV FADVTDEMTI AREEIFGPVM CVLDFDDEAE VVARANATEF GLSAGVFTAD 430 440 450 460 470 480 LTRAHRVVDR LEAGTLWINT YNLCPVEIPF GGSKQSGFGR ENSAEALKHY TELKTVYVGM GPVEAPY

References

[1]

"Complete sequence of Sinorhizobium medicae WSM419 chromosome." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000738 Genomic DNA. Translation: ABR59419.1.
RefSeq	YP_001326254.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5321399.
GenomeReviews	Gene locus Smed_0563 in contig CP000738_GR.
KEGG	smd:Smed_0563.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A6U6Y9. VFKPSEN.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_SINMW

Accession

Primary (citable) accession number: A6U6Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	June 16, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)