A6U6V4 (KHSE_SINMW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Smed_0528

Organism

Sinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]

Taxonomic identifier

366394 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Homoserine kinase HAMAP MF_00301		PRO_1000022589

Sequences

	Sequence		Length	Mass (Da)
	A6U6V4 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: AF6C8D9739ED73FF	FASTA	326	36,633
	10 20 30 40 50 60 MAVYTDITED ELIRFLAAYE VGSLTSYKGI AEGVENSNFL LHTTRGAYIL TLYEKRVNAD 70 80 90 100 110 120 DLPFFLGLMH HLAQRGLSCP LPLPRADGKL LGTLSGRPAA VISFLEGMWL RKPEAQHCRE 130 140 150 160 170 180 VGRALALMHQ ASEGFRLKRP NALSVEGWRP LWRNSEARAD EVQAGLKDEI ATELAFLEEH 190 200 210 220 230 240 WPRALPEGVI HADLFPDNVF FLGDRLSGLI DFYFACNDFL AYDIAICLNS WCFEKDGSYN 250 260 270 280 290 300 ITKGMALLSG YESVRNLTAE EVEALPLLAR GSALRFFLTR LYDWLTTPPG ALVVKKDPLE 310 320 YLTKIRFHRA IVSSAEYGLR REEASA

References

[1]

"Complete sequence of Sinorhizobium medicae WSM419 chromosome." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WSM419.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000738 Genomic DNA. Translation: ABR59384.1.
RefSeq	YP_001326219.1. NC_009636.1.
3D structure databases
ProteinModelPortal	A6U6V4.
SMR	A6U6V4. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	A6U6V4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5321362.
GenomeReviews	Gene locus Smed_0528 in contig CP000738_GR.
KEGG	smd:Smed_0528.
PATRIC	23619902. VBISinMed134228_3615.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	SMED366394:SMED_0528-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_SINMW

Accession

Primary (citable) accession number: A6U6V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program