Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6U5X9 (PNCB_SINMW) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:Smed_0200
OrganismSinorhizobium medicae (strain WSM419) (Ensifer medicae) [Complete proteome] [HAMAP]
Taxonomic identifier366394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000025015

Sequences

Sequence LengthMass (Da)Tools
A6U5X9 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: B0CE6AC13437B653

FASTA43449,701
        10         20         30         40         50         60 
MPKTDIARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWQ LYPDVDATFS LINRTKTVRL 

        70         80         90        100        110        120 
ADEIDEQELR DQLDHARGLR FTKKEMIWLA GNSFYGRKQI FAPEFLVWLA KFRLPPYELS 

       130        140        150        160        170        180 
RRDGQFELTF RGRWAETTMW EIPALAIINE LRSRAAMKGL GPFTLDVLYA RAKARMWLKV 

       190        200        210        220        230        240 
EQLREHPNLR ISDFGTRRRH SFLWQRWCVE ALKEGIGPSF TGSSNVLLAM DNDLEAVGTN 

       250        260        270        280        290        300 
AHELPMVAAA LARNDRELAA APYKVLQDWN QLYGGNLLIV LPDAFGTAAF LRDAPDWVAD 

       310        320        330        340        350        360 
WTGFRPDSAP PIEGGEKIIA WWKKMGRDPR EKLLIFSDGL DVDTIVKTYC HFEGRVRMSF 

       370        380        390        400        410        420 
GWGTNLTNDF AGCAPTEING LNPISVVCKV SEANGHPAVK LSDNPRKATG DPGEVERYLR 

       430 
FFGSEDFVEQ SVRV 

« Hide

References

[1]"Complete sequence of Sinorhizobium medicae WSM419 chromosome."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM419.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000738 Genomic DNA. Translation: ABR59059.1.
RefSeqYP_001325894.1. NC_009636.1.

3D structure databases

ProteinModelPortalA6U5X9.
SMRA6U5X9. Positions 1-426.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING366394.Smed_0200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR59059; ABR59059; Smed_0200.
GeneID5321030.
KEGGsmd:Smed_0200.
PATRIC23619189. VBISinMed134228_3263.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284929.
KOK00763.
OMAKLTMQCA.
OrthoDBEOG6X10XB.
ProtClustDBPRK05321.

Enzyme and pathway databases

BioCycSMED366394:GJAL-203-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_SINMW
AccessionPrimary (citable) accession number: A6U5X9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: March 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways