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Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus aureus (strain JH1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 12990cNMPAdd
BLAST
DNA bindingi188 – 20720H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. cAMP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

cAMP, cAMP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR359787:GCG4-2789-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ArcR
Gene namesi
Name:arcR
Ordered Locus Names:SaurJH1_2711
OrganismiStaphylococcus aureus (strain JH1)
Taxonomic identifieri359787 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001109 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234HTH-type transcriptional regulator ArcRPRO_0000349406Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359787.SaurJH1_2711.

Structurei

3D structure databases

ProteinModelPortaliA6U515.
SMRiA6U515. Positions 31-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 22874HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000022896.
OMAiERVNQNG.
OrthoDBiEOG6QRWC5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6U515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY
60 70 80 90 100
FSPQESSNIY FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV
110 120 130 140 150
NELCTALTDC TVLGLPRELM AFLCKANDDI FLTLFALIND NEQQHMNYNM
160 170 180 190 200
ALTSKFAKDR IIKLLCHLCQ TVGYDQDEFY EIKQFLTIQL MSDMAGISRE
210 220 230
TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV
Length:234
Mass (Da):27,428
Last modified:August 21, 2007 - v1
Checksum:iA63E59D8A1ED4E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000736 Genomic DNA. Translation: ABR53533.1.
RefSeqiYP_001317820.1. NC_009632.1.

Genome annotation databases

EnsemblBacteriaiABR53533; ABR53533; SaurJH1_2711.
KEGGisah:SaurJH1_2711.
PATRICi19537408. VBIStaAur98826_2762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000736 Genomic DNA. Translation: ABR53533.1.
RefSeqiYP_001317820.1. NC_009632.1.

3D structure databases

ProteinModelPortaliA6U515.
SMRiA6U515. Positions 31-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359787.SaurJH1_2711.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR53533; ABR53533; SaurJH1_2711.
KEGGisah:SaurJH1_2711.
PATRICi19537408. VBIStaAur98826_2762.

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000022896.
OMAiERVNQNG.
OrthoDBiEOG6QRWC5.

Enzyme and pathway databases

BioCyciSAUR359787:GCG4-2789-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH1."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JH1.

Entry informationi

Entry nameiARCR_STAA2
AccessioniPrimary (citable) accession number: A6U515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 21, 2007
Last modified: April 1, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.