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Protein

Copper-exporting P-type ATPase A

Gene

copA

Organism
Staphylococcus aureus (strain JH1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in copper export.By similarity

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi16 – 161Copper 1PROSITE-ProRule annotation
Metal bindingi19 – 191Copper 1PROSITE-ProRule annotation
Metal bindingi83 – 831Copper 2PROSITE-ProRule annotation
Metal bindingi86 – 861Copper 2PROSITE-ProRule annotation
Active sitei495 – 49514-aspartylphosphate intermediateBy similarity
Metal bindingi690 – 6901MagnesiumPROSITE-ProRule annotation
Metal bindingi694 – 6941MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR359787:GCG4-2711-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-exporting P-type ATPase A (EC:3.6.3.54)
Alternative name(s):
Cu(+)-exporting ATPase
Gene namesi
Name:copA
Ordered Locus Names:SaurJH1_2633
OrganismiStaphylococcus aureus (strain JH1)
Taxonomic identifieri359787 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence analysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence analysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Transmembranei748 – 76720HelicalSequence analysisAdd
BLAST
Transmembranei771 – 79020HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Copper-exporting P-type ATPase APRO_0000350585Add
BLAST

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliA6U4T8.
SMRiA6U4T8. Positions 1-140, 163-795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7166HMA 1PROSITE-ProRule annotationAdd
BLAST
Domaini73 – 13967HMA 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 HMA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250397.
KOiK17686.
OMAiQDGSTDH.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6U4T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTKKTTLD ITGMTCAACS NRIEKKLNKL DDVNAQVNLT TEKATVEYNP
60 70 80 90 100
DQHDVQEFIN TIQHLGYGVT VETVELDITG MTCAACSSRI EKVLNKMNGV
110 120 130 140 150
QNATVNLTTE QAKVDYYPEE TDADKLVTRI QKLGYDASIK DNNKDQTSRK
160 170 180 190 200
AEALQHKLIK LIISAVLSLP LLMLMFVHLF NMHIPALFTN PWFQFILATP
210 220 230 240 250
VQFIIGWQFY VGAYKNLRNG GANMDVLVAV GTSAAYFYSI YEMVRWLNGS
260 270 280 290 300
TTQPHLYFET SAVLLTLILF GKYLEARAKS QTTNALGELL SLQAKEARIL
310 320 330 340 350
KDGNEVMIPL NEVHVGDTLI VKPGEKIPVD GKIIKGMTAI DESMLTGESI
360 370 380 390 400
PVEKNVDDTV IGSTMNKNGT ITMTATKVGG DTALANIIKV VEEAQSSKAP
410 420 430 440 450
IQRLADIISG YFVPIVVGIA LLIFIVWITL VTPGTFEPAL VASISVLVIA
460 470 480 490 500
CPCALGLATP TSIMVGTGRA AENGILFKGG EFVERTHQID TIVLDKTGTI
510 520 530 540 550
TNGRPVVTDY HGDNQTLQLL ATAEKDSEHP LAEAIVNYAK EKQLTLTETT
560 570 580 590 600
TFKAVPGHGI EATIDHHHIL VGNRKLMADN DISLPKHISD DLTHYERDGK
610 620 630 640 650
TAMLIAVNYS LTGIIAVADT VKDHAKDAIK QLHDMGIEVA MLTGDNKNTA
660 670 680 690 700
QAIAKQVGID TVIADILPEE KAAQIAKLQQ QGKKVAMVGD GVNDAPALVK
710 720 730 740 750
ADIGIAIGTG TEVAIEAADI TILGGDLMLI PKAIYASKAT IRNIRQNLFW
760 770 780 790 800
AFGYNIAGIP IAALGLLAPW VAGAAMALSS VSVVTNALRL KKMRLEPRRK

DA
Length:802
Mass (Da):86,773
Last modified:August 21, 2007 - v1
Checksum:i2BCC0B7D7E173DDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000736 Genomic DNA. Translation: ABR53456.1.
RefSeqiWP_000024139.1. NC_009632.1.

Genome annotation databases

EnsemblBacteriaiABR53456; ABR53456; SaurJH1_2633.
KEGGisah:SaurJH1_2633.
PATRICi19537252. VBIStaAur98826_2684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000736 Genomic DNA. Translation: ABR53456.1.
RefSeqiWP_000024139.1. NC_009632.1.

3D structure databases

ProteinModelPortaliA6U4T8.
SMRiA6U4T8. Positions 1-140, 163-795.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR53456; ABR53456; SaurJH1_2633.
KEGGisah:SaurJH1_2633.
PATRICi19537252. VBIStaAur98826_2684.

Phylogenomic databases

HOGENOMiHOG000250397.
KOiK17686.
OMAiQDGSTDH.

Enzyme and pathway databases

BioCyciSAUR359787:GCG4-2711-MONOMER.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOPA_STAA2
AccessioniPrimary (citable) accession number: A6U4T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.