A6U2J5 (SYY_STAA2) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 46.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Tyrosine--tRNA ligase EC=6.1.1.1 Alternative name(s): Tyrosyl-tRNA synthetase Short name=TyrRS | ||||
| Gene names |
| ||||
| Organism | Staphylococcus aureus (strain JH1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 359787 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus › ![]() |
Protein attributes
| Sequence length | 420 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) By similarity. HAMAP-Rule MF_02006 |
| Catalytic activity | ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). HAMAP-Rule MF_02006 |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. Contains 1 S4 RNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding RNA-binding |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | tyrosyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: HAMAP RNA bindingInferred from electronic annotation. Source: UniProtKB-KW tyrosine-tRNA ligase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 420 | 420 | Tyrosine--tRNA ligase HAMAP-Rule MF_02006 | PRO_1000088627 | |||||
Regions | |||||||||
| Domain | 353 – 420 | 68 | S4 RNA-binding | ||||||
| Motif | 41 – 50 | 10 | "HIGH" region HAMAP-Rule MF_02006 | ||||||
| Motif | 231 – 235 | 5 | "KMSKS" region HAMAP-Rule MF_02006 | ||||||
Sites | |||||||||
| Binding site | 36 | 1 | Tyrosine By similarity | ||||||
| Binding site | 170 | 1 | Tyrosine By similarity | ||||||
| Binding site | 174 | 1 | Tyrosine By similarity | ||||||
| Binding site | 234 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. Richardson P.Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JH1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000736 Genomic DNA. Translation: ABR52663.1. |
| RefSeq | YP_001316950.1. NC_009632.1. |
3D structure databases | |
| ProteinModelPortal | A6U2J5. |
| SMR | A6U2J5. Positions 2-419. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 359787.SaurJH1_1819. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | ABR52663; ABR52663; SaurJH1_1819. |
| GeneID | 5316809. |
| KEGG | sah:SaurJH1_1819. |
| PATRIC | 19535504. VBIStaAur98826_1862. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0162. |
| HOGENOM | HOG000242790. |
| KO | K01866. |
| OMA | GKKKHVL. |
| ProtClustDB | PRK05912. |
Family and domain databases | |
| Gene3D | 3.10.290.10. 1 hit. 3.40.50.620. 1 hit. |
| HAMAP | MF_02006. Tyr_tRNA_synth_type1. |
| InterPro | IPR001412. aa-tRNA-synth_I_CS. IPR002305. aa-tRNA-synth_Ic. IPR014729. Rossmann-like_a/b/a_fold. IPR002942. S4_RNA-bd. IPR002307. Tyr-tRNA-ligase. IPR024088. Tyr-tRNA-ligase_bac-type. IPR024107. Tyr-tRNA-ligase_bac_1. [Graphical view] |
| PANTHER | PTHR11766. PTHR11766. 1 hit. |
| Pfam | PF01479. S4. 1 hit. PF00579. tRNA-synt_1b. 1 hit. [Graphical view] |
| PRINTS | PR01040. TRNASYNTHTYR. |
| SMART | SM00363. S4. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00234. tyrS. 1 hit. |
| PROSITE | PS00178. AA_TRNA_LIGASE_I. 1 hit. PS50889. S4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| BindingDB | A6U2J5. |
Entry information
| Entry name | SYY_STAA2 | ||||||||
| Accession | Primary (citable) accession number: A6U2J5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with
