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A6U2H8 (ACKA_STAA2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetate kinase
EC=2.7.2.1
Alternative name(s):
Acetokinase
Gene names
Name:ackA
Ordered Locus Names:SaurJH1_1802
OrganismStaphylococcus aureus (strain JH1) [Complete proteome] [HAMAP]
Taxonomic identifier359787 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020

ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020

Subcellular location

Cytoplasm By similarity HAMAP MF_00020.

Sequence similarities

Belongs to the acetokinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processorganic acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Acetate kinase HAMAP MF_00020
PRO_1000074192

Sequences

Sequence LengthMass (Da)Tools
A6U2H8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 8454A0F6CA3BAEA9

FASTA40044,043
        10         20         30         40         50         60 
MSKLILAINA GSSSLKFQLI RMPEEELVTK GLIERIGLKD SIFTIEVNGE KVKTVQDIKD 

        70         80         90        100        110        120 
HVEAVDIMLD AFKAHNIIND INDIDGTGHR VVHGGEKFPE SVAITDEVEK EIEELSELAP 

       130        140        150        160        170        180 
LHNPANLMGI RAFRKLLPNI PHVAIFDTAF HQTMPEKAYL YSLPYHYYKD YGIRKYGFHG 

       190        200        210        220        230        240 
TSHKFVSQRA AEMLDKPVED LRIISCHIGN GASIAAIDGG KSIDTSMGFT PLAGVTMGTR 

       250        260        270        280        290        300 
SGNIDPALIP FIMEKTGKTA EQVLEILNKE SGLLGLSGTS SDLRDLSEEA ESGKARSQMA 

       310        320        330        340        350        360 
LDVFASKIHK YIGSYAARMH GVDVIVFTAG IGENSVEIRA KVLEGLEFMG VYWDPKKNEN 

       370        380        390        400 
LLRGKEGFIN YPHSPVKVVV IPTDEESMIA RDVMTFGGLK

« Hide

References

[1]"Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000736 Genomic DNA. Translation: ABR52646.1.
RefSeqYP_001316933.1. NC_009632.1.

3D structure databases

ProteinModelPortalA6U2H8.
SMRA6U2H8. Positions 5-396.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6U2H8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000015136; EBSTAP00000014639; EBSTAG00000015135.
GeneID5315832.
GenomeReviewsGene locus SaurJH1_1802 in contig CP000736_GR.
KEGGsah:SaurJH1_1802.
PATRIC19535470. VBIStaAur98826_1845.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0282.
GeneTreeEBGT00050000024640.
HOGENOMHBG285863.
OMALIDMTNE.
ProtClustDBPRK00180.

Enzyme and pathway databases

BioCycSAUR359787:SAURJH1_1802-MONOMER.

Family and domain databases

HAMAPMF_00020. Acetate_kinase.
[Tree]
InterProIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
KOK00925.
PANTHERPTHR21060. Acetate_kin. 1 hit.
PfamPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSPR00471. ACETATEKNASE.
TIGRFAMsTIGR00016. AckA. 1 hit.
PROSITEPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACKA_STAA2
AccessionPrimary (citable) accession number: A6U2H8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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