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Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Staphylococcus aureus (strain JH1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391NucleophileUniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciSAUR359787:GCG4-1383-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:SaurJH1_1357
OrganismiStaphylococcus aureus (strain JH1)
Taxonomic identifieri359787 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001109: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305tRNA pseudouridine synthase BPRO_1000084689Add
BLAST

Proteomic databases

PRIDEiA6U190.

Interactioni

Protein-protein interaction databases

STRINGi359787.SaurJH1_1357.

Structurei

3D structure databases

ProteinModelPortaliA6U190.
SMRiA6U190. Positions 1-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0130.
HOGENOMiHOG000231225.
KOiK03177.
OMAiYELQFIR.
OrthoDBiEOG6358D3.

Family and domain databases

HAMAPiMF_01080. TruB_bact.
InterProiIPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR014780. tRNA_psdUridine_synth_TruB.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.

Sequencei

Sequence statusi: Complete.

A6U190-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYNGILPVYK ERGLTSHDVV FKLRKILKTK KIGHTGTLDP EVAGVLPVCI
60 70 80 90 100
GNATRVSDYV MDMGKAYEAT VSIGRSTTTE DQTGDTLETK GVHSADFNKD
110 120 130 140 150
DIDRLLENFK GVIEQIPPMY SSVKVNGKKL YEYARNNETV ERPKRKVNIK
160 170 180 190 200
DIGRISELDF KENECHFKIR VICGKGTYIR TLATDIGVKL GFPAHMSKLT
210 220 230 240 250
RIESGGFVLK DSLTLEQIKE LHEQDSLQNK LFPLEYGLKG LPSIKIKDSH
260 270 280 290 300
IKKRILNGQK FNKNEFDNKI KDQIVFIDDD SEKVLAIYMV HPTKESEIKP

KKVFN
Length:305
Mass (Da):34,606
Last modified:August 21, 2007 - v1
Checksum:i59510CA2C74F3F34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000736 Genomic DNA. Translation: ABR52208.1.
RefSeqiYP_001316495.1. NC_009632.1.

Genome annotation databases

EnsemblBacteriaiABR52208; ABR52208; SaurJH1_1357.
GeneIDi5315482.
KEGGisah:SaurJH1_1357.
PATRICi19534564. VBIStaAur98826_1391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000736 Genomic DNA. Translation: ABR52208.1.
RefSeqiYP_001316495.1. NC_009632.1.

3D structure databases

ProteinModelPortaliA6U190.
SMRiA6U190. Positions 1-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359787.SaurJH1_1357.

Proteomic databases

PRIDEiA6U190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR52208; ABR52208; SaurJH1_1357.
GeneIDi5315482.
KEGGisah:SaurJH1_1357.
PATRICi19534564. VBIStaAur98826_1391.

Phylogenomic databases

eggNOGiCOG0130.
HOGENOMiHOG000231225.
KOiK03177.
OMAiYELQFIR.
OrthoDBiEOG6358D3.

Enzyme and pathway databases

BioCyciSAUR359787:GCG4-1383-MONOMER.

Family and domain databases

HAMAPiMF_01080. TruB_bact.
InterProiIPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR014780. tRNA_psdUridine_synth_TruB.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH1."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JH1.

Entry informationi

Entry nameiTRUB_STAA2
AccessioniPrimary (citable) accession number: A6U190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.