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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Staphylococcus aureus (strain JH1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:SaurJH1_1266
OrganismiStaphylococcus aureus (strain JH1)
Taxonomic identifieri359787 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei50 – 70HelicalUniRule annotationAdd BLAST21
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Transmembranei112 – 132HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei225 – 245HelicalUniRule annotationAdd BLAST21
Transmembranei250 – 270HelicalUniRule annotationAdd BLAST21
Transmembranei300 – 320HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000745641 – 321Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST321

Structurei

3D structure databases

ProteinModelPortaliA6U102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6U102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFVYALLAL VITFVLVPVL IPTLKRMKFG QSIREEGPQS HMKKTGTPTM
60 70 80 90 100
GGLTFLLSIV ITSLVAIIFV DQANPIILLL FVTIGFGLIG FIDDYIIVVK
110 120 130 140 150
KNNQGLTSKQ KFLAQIGIAI IFFVLSNVFH LVNFSTSIHI PFTNVAIPLS
160 170 180 190 200
FAYVIFIVFW QVGFSNAVNL TDGLDGLATG LSIIGFTMYA IMSFVLGETA
210 220 230 240 250
IGIFCIIMLF ALLGFLPYNI NPAKVFMGDT GSLALGGIFA TISIMLNQEL
260 270 280 290 300
SLIFIGLVFV IETLSVMLQV ASFKLTGKRI FKMSPIHHHF ELIGWSEWKV
310 320
VTVFWAVGLI SGLIGLWIGV H
Length:321
Mass (Da):35,232
Last modified:August 21, 2007 - v1
Checksum:i0A2F82D042255848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000736 Genomic DNA. Translation: ABR52120.1.
RefSeqiWP_000578458.1. NC_009632.1.

Genome annotation databases

EnsemblBacteriaiABR52120; ABR52120; SaurJH1_1266.
KEGGisah:SaurJH1_1266.

Similar proteinsi

Entry informationi

Entry nameiMRAY_STAA2
AccessioniPrimary (citable) accession number: A6U102
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: June 7, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families