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A6U068

- ASSY_STAA2

UniProt

A6U068 - ASSY_STAA2

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Protein

Argininosuccinate synthase

Gene
argG, SaurJH1_0980
Organism
Staphylococcus aureus (strain JH1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Citrulline By similarity
Binding sitei115 – 1151ATP; via amide nitrogen By similarity
Binding sitei117 – 1171Aspartate By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei121 – 1211Citrulline By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei173 – 1731Citrulline By similarity
Binding sitei258 – 2581Citrulline By similarity
Binding sitei270 – 2701Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR359787:GCG4-1004-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:SaurJH1_0980
OrganismiStaphylococcus aureus (strain JH1)
Taxonomic identifieri359787 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001109: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Argininosuccinate synthaseUniRule annotationPRO_1000073833Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi359787.SaurJH1_0980.

Structurei

3D structure databases

ProteinModelPortaliA6U068.
SMRiA6U068. Positions 2-397.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6U068-1 [UniParc]FASTAAdd to Basket

« Hide

MKEKIVLAYS GGLDTSVAVQ WLIDKGYDVV ACCLDVGEGK DLDIVYKKAL    50
DMGAVECHII DATKEFSDEY VSYAIKGNLM YENAYPLVSA LSRPLIAKKL 100
VEIAEKTNSV GIAHGCTGKG NDQVRFEVAI KALNPSLKAF APVREWAWSR 150
EEEIDYAIKH NIPVSINHDS PYSIDQNLWG RANECGILED PYAAPPEDAF 200
DLTNALEETP DTADEIILTF DKGIPVQIDG KTYELDDLIL TLNALAGKHG 250
IGRIDHVENR LVGIKSREIY EAPAAEVILK AHKALETITL TKDVAHFKPI 300
IEKQFAEQLY NGLWFSPLTD SLKLFIDSTQ QYVSGDVRIK LFKGNAIVNG 350
RKSPYTLYDE KLATYTKEDA FNQDAAVGFI DIYGLPTQVN AMLHGGYSNE 400
Q 401
Length:401
Mass (Da):44,455
Last modified:August 21, 2007 - v1
Checksum:iBAA35E9F6C6FD5A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000736 Genomic DNA. Translation: ABR51836.1.
RefSeqiYP_001316123.1. NC_009632.1.

Genome annotation databases

EnsemblBacteriaiABR51836; ABR51836; SaurJH1_0980.
GeneIDi5315885.
KEGGisah:SaurJH1_0980.
PATRICi19533801. VBIStaAur98826_1013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000736 Genomic DNA. Translation: ABR51836.1 .
RefSeqi YP_001316123.1. NC_009632.1.

3D structure databases

ProteinModelPortali A6U068.
SMRi A6U068. Positions 2-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359787.SaurJH1_0980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR51836 ; ABR51836 ; SaurJH1_0980 .
GeneIDi 5315885.
KEGGi sah:SaurJH1_0980.
PATRICi 19533801. VBIStaAur98826_1013.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SAUR359787:GCG4-1004-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH1."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JH1.

Entry informationi

Entry nameiASSY_STAA2
AccessioniPrimary (citable) accession number: A6U068
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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