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A6TZM2

- PEPT_STAA2

UniProt

A6TZM2 - PEPT_STAA2

Protein

Peptidase T

Gene

pepT

Organism
Staphylococcus aureus (strain JH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

    Catalytic activityi

    Release of the N-terminal residue from a tripeptide.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Zinc 1UniRule annotation
    Active sitei80 – 801UniRule annotation
    Metal bindingi140 – 1401Zinc 1UniRule annotation
    Metal bindingi140 – 1401Zinc 2UniRule annotation
    Active sitei174 – 1741Proton acceptorUniRule annotation
    Metal bindingi175 – 1751Zinc 2UniRule annotation
    Metal bindingi197 – 1971Zinc 1UniRule annotation
    Metal bindingi379 – 3791Zinc 2UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW
    2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSAUR359787:GCG4-805-MONOMER.

    Protein family/group databases

    MEROPSiM20.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
    Alternative name(s):
    AminotripeptidaseUniRule annotation
    Short name:
    TripeptidaseUniRule annotation
    Tripeptide aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepTUniRule annotation
    Ordered Locus Names:SaurJH1_0784
    OrganismiStaphylococcus aureus (strain JH1)
    Taxonomic identifieri359787 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001109: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Peptidase TPRO_1000081962Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359787.SaurJH1_0784.

    Structurei

    3D structure databases

    ProteinModelPortaliA6TZM2.
    SMRiA6TZM2. Positions 1-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20B family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2195.
    HOGENOMiHOG000032390.
    KOiK01258.
    OMAiDCYIEVT.
    OrthoDBiEOG6SV59Q.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_00550. Aminopeptidase_M20.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6TZM2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNQLIDRLT RYTTIDTQSD PKSTTTPSTE KQWDLLHLLE KELQQLGLPT    50
    DLDENGYLFA TLESNIDADV PTVGFLAHVD TSPDFNASNV KPQIIENYDG 100
    KPYKLGNTKR VLDPKVFPEL NSLVGHTLMV TDGTSLLGAD DKAGIVEIME 150
    AICYLQEHPE IKHGTIRIGF TPDEEIGRGP HKFDVDRFNA DFAYTMDGSQ 200
    YGELQYESFN AAEAVITCHG VNVHPGSAKN AMVNAIRLGE QFDSLLPDSE 250
    VPERTEGYEG FYHLMNFEGT VEKATLQYII RDHDKKQFEL RKKRILEIRD 300
    DINAHFENYP VKVDISDQYF NMAEKILPLP HIIDIPKRVF AKLDIPANTE 350
    PIRGGTDGSQ LSFMGLPTPN IFTGCGNFHG PYEYASIDVM EKAVQVIIGI 400
    VEDIAENH 408
    Length:408
    Mass (Da):45,820
    Last modified:August 21, 2007 - v1
    Checksum:i28A88DC436056671
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000736 Genomic DNA. Translation: ABR51640.1.
    RefSeqiYP_001315927.1. NC_009632.1.

    Genome annotation databases

    EnsemblBacteriaiABR51640; ABR51640; SaurJH1_0784.
    GeneIDi5315776.
    KEGGisah:SaurJH1_0784.
    PATRICi19533415. VBIStaAur98826_0820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000736 Genomic DNA. Translation: ABR51640.1 .
    RefSeqi YP_001315927.1. NC_009632.1.

    3D structure databases

    ProteinModelPortali A6TZM2.
    SMRi A6TZM2. Positions 1-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359787.SaurJH1_0784.

    Protein family/group databases

    MEROPSi M20.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR51640 ; ABR51640 ; SaurJH1_0784 .
    GeneIDi 5315776.
    KEGGi sah:SaurJH1_0784.
    PATRICi 19533415. VBIStaAur98826_0820.

    Phylogenomic databases

    eggNOGi COG2195.
    HOGENOMi HOG000032390.
    KOi K01258.
    OMAi DCYIEVT.
    OrthoDBi EOG6SV59Q.

    Enzyme and pathway databases

    BioCyci SAUR359787:GCG4-805-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_00550. Aminopeptidase_M20.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH1."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JH1.

    Entry informationi

    Entry nameiPEPT_STAA2
    AccessioniPrimary (citable) accession number: A6TZM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3