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Protein

Peptidase T

Gene

pepT

Organism
Staphylococcus aureus (strain JH1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Zinc 1UniRule annotation
Active sitei80 – 801UniRule annotation
Metal bindingi140 – 1401Zinc 1UniRule annotation
Metal bindingi140 – 1401Zinc 2UniRule annotation
Active sitei174 – 1741Proton acceptorUniRule annotation
Metal bindingi175 – 1751Zinc 2UniRule annotation
Metal bindingi197 – 1971Zinc 1UniRule annotation
Metal bindingi379 – 3791Zinc 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSAUR359787:GCG4-805-MONOMER.

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
Alternative name(s):
AminotripeptidaseUniRule annotation
Short name:
TripeptidaseUniRule annotation
Tripeptide aminopeptidaseUniRule annotation
Gene namesi
Name:pepTUniRule annotation
Ordered Locus Names:SaurJH1_0784
OrganismiStaphylococcus aureus (strain JH1)
Taxonomic identifieri359787 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Peptidase TPRO_1000081962Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA6TZM2.
SMRiA6TZM2. Positions 1-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
KOiK01258.
OMAiYVYATIP.
OrthoDBiEOG6SV59Q.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6TZM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNQLIDRLT RYTTIDTQSD PKSTTTPSTE KQWDLLHLLE KELQQLGLPT
60 70 80 90 100
DLDENGYLFA TLESNIDADV PTVGFLAHVD TSPDFNASNV KPQIIENYDG
110 120 130 140 150
KPYKLGNTKR VLDPKVFPEL NSLVGHTLMV TDGTSLLGAD DKAGIVEIME
160 170 180 190 200
AICYLQEHPE IKHGTIRIGF TPDEEIGRGP HKFDVDRFNA DFAYTMDGSQ
210 220 230 240 250
YGELQYESFN AAEAVITCHG VNVHPGSAKN AMVNAIRLGE QFDSLLPDSE
260 270 280 290 300
VPERTEGYEG FYHLMNFEGT VEKATLQYII RDHDKKQFEL RKKRILEIRD
310 320 330 340 350
DINAHFENYP VKVDISDQYF NMAEKILPLP HIIDIPKRVF AKLDIPANTE
360 370 380 390 400
PIRGGTDGSQ LSFMGLPTPN IFTGCGNFHG PYEYASIDVM EKAVQVIIGI

VEDIAENH
Length:408
Mass (Da):45,820
Last modified:August 21, 2007 - v1
Checksum:i28A88DC436056671
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000736 Genomic DNA. Translation: ABR51640.1.
RefSeqiWP_000795811.1. NC_009632.1.

Genome annotation databases

EnsemblBacteriaiABR51640; ABR51640; SaurJH1_0784.
KEGGisah:SaurJH1_0784.
PATRICi19533415. VBIStaAur98826_0820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000736 Genomic DNA. Translation: ABR51640.1.
RefSeqiWP_000795811.1. NC_009632.1.

3D structure databases

ProteinModelPortaliA6TZM2.
SMRiA6TZM2. Positions 1-406.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM20.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR51640; ABR51640; SaurJH1_0784.
KEGGisah:SaurJH1_0784.
PATRICi19533415. VBIStaAur98826_0820.

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
KOiK01258.
OMAiYVYATIP.
OrthoDBiEOG6SV59Q.

Enzyme and pathway databases

BioCyciSAUR359787:GCG4-805-MONOMER.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH1."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JH1.

Entry informationi

Entry nameiPEPT_STAA2
AccessioniPrimary (citable) accession number: A6TZM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.