Reviewed, UniProtKB/Swiss-Prot A6TWW1 (OTC_ALKMQ)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	Amet_4608

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000084833
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	272 – 275	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6TWW1-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: E1544D36556A743E	FASTA	330	36,858
	10 20 30 40 50 60 MPVNLKGRSF LTLKDFTSQE IQHLLDLSRD LKAKKRMGVK GESLLGKNIV LLFEKASTRT 70 80 90 100 110 120 RCAFEVAALD EGAHVTFLGS NDSQIGKKES IEDTAKVLGR FYDGMEFRGF KQETVETLAA 130 140 150 160 170 180 HAGIPVWNGL TDLYHPTQIL ADFLTIMEHI DKPLNKVKFA YVGDARNNMG NSLMIGAAKM 190 200 210 220 230 240 GMDFRAVAPK ELLPKGELVE EMRAVAAETG GEITLTDDVA EGVKDADVIY TDVWVSMGEE 250 260 270 280 290 300 DQFEVRIKQL LPYQVNMDMI KATGNPDMIF MHCLPAFHDL ETTVGKEIHE KFGLKSMEVT 310 320 330 DEVFRSRHSV VFDEAENRLH TIKAIMVATL

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000724 Genomic DNA. Translation: ABR50679.1.
RefSeq	YP_001322338.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6TWW1.
Genome annotation databases
GeneID	5314771.
GenomeReviews	Gene locus Amet_4608 in contig CP000724_GR.
KEGG	amt:Amet_4608.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NPNVKFM.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_ALKMQ

Accession

Primary (citable) accession number: A6TWW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)