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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Alkaliphilus metalliredigens (strain QYMF)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciAMET293826:G1G94-4409-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Amet_4339
OrganismiAlkaliphilus metalliredigens (strain QYMF)
Taxonomic identifieri293826 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
Proteomesi
  • UP000001572 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei41 – 61HelicalUniRule annotationAdd BLAST21
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei118 – 138HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei223 – 243HelicalUniRule annotationAdd BLAST21
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000627841 – 275Undecaprenyl-diphosphataseAdd BLAST275

Proteomic databases

PRIDEiA6TW45

Interactioni

Protein-protein interaction databases

STRINGi293826.Amet_4339

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218357
KOiK06153
OMAiWEFLATG
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

A6TW45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFKAILLG IVQGLTEFLP VSSSGHLAVT QHLLGVPEDR ILFLTILLHV
60 70 80 90 100
GTLFSVFFVY ADDIFMICKE FILMIVDLLT GKGIRVNNQY RKLGLLIIVA
110 120 130 140 150
TIPTGIIGLF FKDLFTSFYN STLIIGISLL VTGTLLWTAE KVNTGKRDIK
160 170 180 190 200
DMNWFDAVIV GLFQGLAITP GISRSGSTIV GSLFRGFNKE LATKFSFLIS
210 220 230 240 250
IPAILGATVF EVKDVLEVGL GDFTLTMLIA GVLASFLSGV FAIRTLINFI
260 270
KKEKLYYFSY YTWTVGSIVI LFSLL
Length:275
Mass (Da):30,322
Last modified:August 21, 2007 - v1
Checksum:i7A1AB80CFD03FE80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000724 Genomic DNA Translation: ABR50413.1
RefSeqiWP_012065360.1, NC_009633.1

Genome annotation databases

EnsemblBacteriaiABR50413; ABR50413; Amet_4339
KEGGiamt:Amet_4339

Similar proteinsi

Entry informationi

Entry nameiUPPP_ALKMQ
AccessioniPrimary (citable) accession number: A6TW45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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