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A6TW45

- UPPP_ALKMQ

UniProt

A6TW45 - UPPP_ALKMQ

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Alkaliphilus metalliredigens (strain QYMF)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciAMET293826:GI5P-4472-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Amet_4339
    OrganismiAlkaliphilus metalliredigens (strain QYMF)
    Taxonomic identifieri293826 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeAlkaliphilus
    ProteomesiUP000001572: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Undecaprenyl-diphosphatasePRO_1000062784Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi293826.Amet_4339.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei95 – 11521HelicalUniRule annotationAdd
    BLAST
    Transmembranei118 – 13821HelicalUniRule annotationAdd
    BLAST
    Transmembranei192 – 21221HelicalUniRule annotationAdd
    BLAST
    Transmembranei223 – 24321HelicalUniRule annotationAdd
    BLAST
    Transmembranei255 – 27521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiISTHRFT.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6TW45-1 [UniParc]FASTAAdd to Basket

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    MTTFKAILLG IVQGLTEFLP VSSSGHLAVT QHLLGVPEDR ILFLTILLHV    50
    GTLFSVFFVY ADDIFMICKE FILMIVDLLT GKGIRVNNQY RKLGLLIIVA 100
    TIPTGIIGLF FKDLFTSFYN STLIIGISLL VTGTLLWTAE KVNTGKRDIK 150
    DMNWFDAVIV GLFQGLAITP GISRSGSTIV GSLFRGFNKE LATKFSFLIS 200
    IPAILGATVF EVKDVLEVGL GDFTLTMLIA GVLASFLSGV FAIRTLINFI 250
    KKEKLYYFSY YTWTVGSIVI LFSLL 275
    Length:275
    Mass (Da):30,322
    Last modified:August 21, 2007 - v1
    Checksum:i7A1AB80CFD03FE80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000724 Genomic DNA. Translation: ABR50413.1.
    RefSeqiWP_012065360.1. NC_009633.1.
    YP_001322072.1. NC_009633.1.

    Genome annotation databases

    EnsemblBacteriaiABR50413; ABR50413; Amet_4339.
    GeneIDi5314499.
    KEGGiamt:Amet_4339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000724 Genomic DNA. Translation: ABR50413.1 .
    RefSeqi WP_012065360.1. NC_009633.1.
    YP_001322072.1. NC_009633.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 293826.Amet_4339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR50413 ; ABR50413 ; Amet_4339 .
    GeneIDi 5314499.
    KEGGi amt:Amet_4339.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi ISTHRFT.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci AMET293826:GI5P-4472-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Alkaliphilus metalliredigens QYMF."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: QYMF.

    Entry informationi

    Entry nameiUPPP_ALKMQ
    AccessioniPrimary (citable) accession number: A6TW45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3