A6TW06 (GLMM_ALKMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	Amet_4300

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_1000068885
Sites
	Active site	100	1	Phosphoserine intermediate By similarity
	Metal binding	100	1	Magnesium; via phosphate group By similarity
	Metal binding	240	1	Magnesium By similarity
	Metal binding	242	1	Magnesium By similarity
	Metal binding	244	1	Magnesium By similarity
Amino acid modifications
	Modified residue	100	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6TW06 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 5950D69B034120C2	FASTA	448	48,600
	10 20 30 40 50 60 MGKLFGTDGI RGIANEELTP ELAYQLGRVG AYVLIKGAKD AKVVIGRDTR ISGDLLTSAI 70 80 90 100 110 120 TSGFLSMGVD VIDLGVIPTP AVAYLTRELQ GNCGIVISAS HNPAEYNGIK FFNHQGYKLP 130 140 150 160 170 180 DEIEEQIETY ILNNEEIENR VTGAAVGKRI ELKEATRLYM DYLKTTIECR FEGLKIAMDL 190 200 210 220 230 240 GNGAVYEAAP QLLKELGAEV IIVNDQPDGM NINEGCGSTH PEVVQRLVKE NKADVGLSFD 250 260 270 280 290 300 GDADRLIAVD NTGAIVDGDS MMAICGTNLN EKHILNKNTI VATVMSNIGL DLAMKEQGCQ 310 320 330 340 350 360 VVKTKVGDRY VLEEMIKEGY TLGGEQSGHI IFLKYNTTGD GLLTALQLIA TVKESGKTLS 370 380 390 400 410 420 ELSGMMTSYP QVLVNAKVKN ENKLAYMEDE VIMGEIKMIE EKMNGVGRVL IRPSGTEPLV 430 440 RVMLEGQEQA ELEVLAHGLA QLIESKLG

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QYMF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000724 Genomic DNA. Translation: ABR50374.1.
RefSeq	YP_001322033.1. NC_009633.1.
3D structure databases
ProteinModelPortal	A6TW06.
ModBase	Search...
Protein-protein interaction databases
STRING	A6TW06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5314381.
GenomeReviews	Gene locus Amet_4300 in contig CP000724_GR.
KEGG	amt:Amet_4300.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HBG644964.
OMA	GVGSTHL.
ProtClustDB	PRK14316.
Enzyme and pathway databases
BioCyc	AMET293826:AMET_4300-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_ALKMQ

Accession

Primary (citable) accession number: A6TW06

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program