Reviewed, UniProtKB/Swiss-Prot A6TVR2 (PYRB_ALKMQ)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Amet_4200

Organism

Alkaliphilus metalliredigens (strain QYMF) [Complete proteome] [HAMAP]

Taxonomic identifier

293826 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Alkaliphilus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Aspartate carbamoyltransferase		PRO_0000321067

Sequences

	Sequence		Length	Mass (Da)
	A6TVR2-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 5E1914E6DC66D065	FASTA	311	35,366
	10 20 30 40 50 60 MSLKGRHLID PNQLSLAELD NIITLGLEIY RNPNHYREIC KGKILGTLFY EPSTRTRLSF 70 80 90 100 110 120 ESAMLRMGGT VLGFSDANTS SAKKGESIAD TIRVLDDYAD LLVMRHPREG APLLASQYAT 130 140 150 160 170 180 VPIVNGGDGG HQHPTQTLTD LITIHHNKGK IENLKVAFCG DLLFGRTVHS LLKTLSRFPN 190 200 210 220 230 240 MEFVFISPSE LKIPKHLKDE VIKSNNVEIV ETTFLEKHMS EIDILYMTRI QKERFFNEEE 250 260 270 280 290 300 YVKLKDSYIL DLQKLRNAKE DLLIMHPLPR VNEIHPEVDT DTRAKYFEQA KLGVYVRMAL 310 MALQLGVIES C

References

[1]

"Complete sequence of Alkaliphilus metalliredigens QYMF." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Ye Q., Zhou J., Fields M., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000724 Genomic DNA. Translation: ABR50280.1.
RefSeq	YP_001321939.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5314281.
GenomeReviews	Gene locus Amet_4200 in contig CP000724_GR.
KEGG	amt:Amet_4200.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ALKMQ

Accession

Primary (citable) accession number: A6TVR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 25, 2008
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)